This episode is the second half of my recent live Q&A. I cover what I’m doing to try to prevent Alzheimer’s, how to change when you can see exactly what’s keeping you stuck, staying hopeful as current events turn darker, what Quantified Self 2.0 would need to deliver, where psychedelics fit in my life now, how I think about “all-natural” vs. synthetic options, and much more.
Please enjoy!
This episode is brought to you by:
- Helix Sleep premium mattresses: HelixSleep.com/Tim (20% off any purchase)
- Shopify global commerce platform, providing tools to start, grow, market, and manage a retail business: Shopify.com/Tim
- Fin powerful AI Agent for all your customer service: Fin.Ai/Tim
- Eight Sleep Pod 6, which cools or heats each side of the bed, with custom elevation and snoring reduction, and wearable-free sleep tracking: EightSleep.com/Tim
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Transcripts
- This episode (coming soon)
- All episodes
Show Notes
Recommended Reading, Listening, & Viewing
- Fear-Setting: The Most Valuable Exercise I Do Every Month | Tim Ferriss
- Why You Should Define Your Fears Instead of Your Goals | TED
- Forget New Year’s Resolutions and Conduct a ‘Past-Year Review’ Instead | Tim Ferriss
- How to Keep Your Brain Sharp: A Practical Playbook Beyond the Basics | Tommy Wood
- The First-Ever Quantified Self Notes (Plus: LSD as Cognitive Enhancer?) | Tim Ferriss
- Total Immersion: How I Learned to Swim Effortlessly in 10 Days and You Can Too | Tim Ferriss
- Sauna | FoundMyFitness
- Norwegian 4×4 High-Intensity Interval Training | NTNU
- Guide to Zone 2 Training | Peter Attia
- Habit Stacking | James Clear
- Casey Neistat | YouTube
- Wabi-Sabi | Wikipedia
- SWOT Analysis | Wikipedia
- Harvest Now, Decrypt Later | Wikipedia
- Share Your Format Ideas with Tim on X (@tferriss, #format)
Books
- Atomic Habits: An Easy & Proven Way to Build Good Habits & Break Bad Ones by James Clear
- Awareness: Conversations with the Masters by Anthony de Mello
- Conscious Loving: The Journey to Co-Commitment by Gay Hendricks and Kathlyn Hendricks
- Crucial Conversations: Tools for Talking When Stakes Are High, Third Edition by Joseph Grenny, Kerry Patterson, Ron McMillan, Al Switzler, and Emily Gregory
- The Effective Executive: The Definitive Guide to Getting the Right Things Done by Peter F. Drucker
- The 80/20 Principle: The Secret to Achieving More with Less by Richard Koch
- The 15 Commitments of Conscious Leadership: A New Paradigm for Sustainable Success by Jim Dethmer, Diana Chapman, and Kaley Warner Klemp
- The 4-Hour Body: An Uncommon Guide to Rapid Fat-Loss, Incredible Sex, and Becoming Superhuman by Timothy Ferriss
- The 4-Hour Chef: The Simple Path to Cooking Like a Pro, Learning Anything, and Living the Good Life by Timothy Ferriss
- The 4-Hour Workweek: Escape 9-5, Live Anywhere, and Join the New Rich by Timothy Ferriss
- The Happy Body: The Simple Science of Nutrition, Exercise, and Relaxation by Aniela Gregorek and Jerzy Gregorek
- Hard Times: An Oral History of the Great Depression by Studs Terkel
- Lateral Thinking: Creativity Step by Step by Edward de Bono
- Outlive: The Science and Art of Longevity by Peter Attia, MD
- The Philosophy of Cognitive-Behavioural Therapy (CBT): Stoic Philosophy as Rational and Cognitive Psychotherapy by Donald J. Robertson
- The Quantified Self: Learning to Observe by Gary Wolf
- Six Thinking Hats by Edward de Bono
- Total Immersion: The Revolutionary Way to Swim Better, Faster, and Easier by Terry Laughlin
Movies & TV Shows
- MobLand (2025)
- Planet Earth (2006)
- There’s Something About Mary (1998)
Related Research
- IMPACT-1 Study Published in JAMA Psychiatry: Results of TSND-201 (Methylone) in Patients with Severe PTSD | Transcend Therapeutics
- Lithium Deficiency and the Onset of Alzheimer’s Disease | Nature
- Long-Term Improvement in Hippocampal-Dependent Learning Ability in Healthy, Aged Individuals Following High Intensity Interval Training | Aging and Disease
- Melatonin Natural Health Products and Supplements: Presence of Serotonin and Significant Variability of Melatonin Content | Journal of Clinical Sleep Medicine
- The Mitophagy Activator Urolithin A Is Safe and Induces a Molecular Signature of Improved Mitochondrial and Cellular Health in Humans | Nature Metabolism
- Psilocybin Produces Substantial and Sustained Decreases in Depression and Anxiety in Patients with Life-Threatening Cancer | Journal of Psychopharmacology
- Psychedelics as Potent Anti-Inflammatory Therapeutics | Neuropharmacology
- Real-World Effectiveness of a Single-Day Regimen for Transcranial Magnetic Stimulation Using Optimized, Neuroplasticity-Enhanced Techniques in Depression (ONE-D): An Open-Label Case Series | Transcranial Magnetic Stimulation
- Sauna Bathing Is Inversely Associated with Dementia and Alzheimer’s Disease in Middle-Aged Finnish Men | Age and Ageing
- Urolithin A Induces Mitophagy and Prolongs Lifespan in C. elegans and Increases Muscle Function in Rodents | Nature Medicine
Relevant Episodes of The Tim Ferriss Show
- Dr. Peter Attia — The Science and Art of Longevity, Optimizing Protein, Alcohol Rules, Lessons from Glucose Monitoring with CGMs, Boosting Your VO2 Max, Preventing Alzheimer’s Disease, Early Cancer Detection, How to Use DEXA Scans, Nature’s Longevity Drug, and More | The Tim Ferriss Show #661
- Diana Chapman — How to Get Unstuck, Do “The Work,” Take Radical Responsibility, and Reduce Drama in Your Life | The Tim Ferriss Show #536
- James Clear, Atomic Habits — Simple Strategies for Building (and Breaking) Habits, Questions for Personal Mastery and Growth, Tactics for Writing and Launching a Mega-Bestseller, Finding Leverage, and More | The Tim Ferriss Show #648
- How to Use Ketosis for Enhanced Mood, Cognition, and Long-Term Brain Protection — A Practical and Tactical Guide with Dr. Dominic D’Agostino (Plus: Deconstructing Tim’s Latest Keto Experiment) | The Tim Ferriss Show #845
- Q&A with Tim — The 4-Hour Workweek in a World of AI, Rebuilding Personal Agency, The 4-Hour Body After 40, and More | The Tim Ferriss Show #887
- Roland Griffiths, PhD — Life’s Ultimate Glide Path, An Unexpected Stage IV Diagnosis, Facing Death, How Meditation and Psychedelics Can Help, and The Art of Living a Life of Gratitude | The Tim Ferriss Show #641
- Sam Harris, Ph.D. — How to Master Your Mind | The Tim Ferriss Show #342
- Legendary Inventor Danny Hillis (Plus Kevin Kelly) — Unorthodox Lessons from 400+ Patents, Solving the Impossible, Real AI vs. “AI,” Hiring Richard Feynman, Working with Steve Jobs, Creating Parallel Computing, and Much More | The Tim Ferriss Show #782
- Sami Inkinen of Virta Health — Reversing Type 2 Diabetes, Rowing 2,750 Miles, and Lessons from Fixing Metabolic Health in 100,000+ People | The Tim Ferriss Show #866
- Hugh Jackman on Best Decisions, Daily Routines, The 85% Rule, Favorite Exercises, Mind Training, and Much More | The Tim Ferriss Show #444
- Richard Koch on Mastering the 80/20 Principle, Achieving Unreasonable Success, and the Art of Gambling | The Tim Ferriss Show #466
- Terry Laughlin, The Master Who Changed My Life | The Tim Ferriss Show #276
- My Two-Year Secret Project, COYOTE — The Strategies and Tactics for Building a Bestseller from Nothing with Elan Lee of Exploding Kittens | The Tim Ferriss Show #821
- The Man Who Taught Me How to Invest — Mike Maples | The Tim Ferriss Show #286
- Hamilton Morris and Dr. Mark Plotkin: Exploring the History of Psychoactive Substances, Synthetic vs. Natural Options, Microdosing, 5-MeO-DMT, The “Drunken Monkey” Hypothesis, Timothy Leary’s Legacy, and More | The Tim Ferriss Show #605
- Hamilton Morris on Iboga, 5-MeO-DMT, the Power of Ritual, New Frontiers in Psychedelics, Excellent Problems to Solve, and More | The Tim Ferriss Show #511
- Dustin Moskovitz, Co-Founder of Asana and Facebook — Energy Management, Coaching for Endurance, No Meeting Wednesdays, Understanding the Real Risks of AI, Embracing Frictionless Work with AI, The Value of Holding Stories Loosely, and More | The Tim Ferriss Show #686
- Casey Neistat Breaks Rules, Reinvents Himself, and Gets Thanked For It | The Tim Ferriss Show #116
- Chris Palmer, MD, of Harvard Medical School — Optimizing Brain Energy for Mental Health, The Incredible Potential of Metabolic Psychiatry, Extraordinary Case Studies, and Harnessing Mitochondria for Anxiety, Depression, OCD, PTSD, and More | The Tim Ferriss Show #633
- Rhonda Patrick, Ph.D. — Protocols for Fasting, Lowering Dementia Risk, Reversing Heart Aging, Using Sauna for Longevity (Hotter is Not Better), and a Few Supplements That Might Actually Matter | The Tim Ferriss Show #819
- The Random Show — AI Super Assistants, Boner Pills, Dream Engineering, Wizards, Supplements, Books, and More | The Tim Ferriss Show #886
- How to Spot 10-Year Trends and Build Billion-Dollar Companies — Kevin Ryan | The Tim Ferriss Show #884
- Richard Schwartz — IFS, Psychedelic Experiences without Drugs, and Finding Inner Peace for Our Many Parts | The Tim Ferriss Show #492
- The Secrets of Gymnastic Strength Training | The Tim Ferriss Show #158
- Pavel Tsatsouline and Christopher Sommer | The Tim Ferriss Show #748
- A Glimpse of the Future: Electroceuticals for 70%–90% Remission of Depression, Brain Stimulation for Sports Performance, and De-risking Ibogaine for TBI/PTSD | The Tim Ferriss Show #714
- Dr. Tommy Wood — How to Future-Proof Your Brain from Dementia | The Tim Ferriss Show #851
Health, Science, & Biotech
- Apolipoprotein E (APOE)
- Bite Mouthwash Bits
- Ephedrine
- Examine
- Ezetimibe (Zetia)
- Hemoglobin A1C
- Ketogenic Diet
- Lithium Orotate
- Ma Huang
- Metabolomics
- Metformin
- Morpheus Heart Rate Monitor
- Oral Glucose Tolerance Test (OGTT)
- Oura Ring
- Philips Sonicare Electric Toothbrushes
- Proteomics
- Red Yeast Rice
- Statins
- Thera Cane Massager
- Therabody Theragun Massage Devices
- Timeline Mitopure Urolithin A
- Tirzepatide
- Transcend Therapeutics
- Transcranial Magnetic Stimulation (TMS)
- Virta Health
- VO₂ Max
- Waterpik
- WHOOP
- Xylitol Gum
Psychedelics
- Ayahuasca
- Banisteriopsis caapi
- Chacruna (Psychotria viridis)
- Dimethyltryptamine (N,N-DMT)
- Ego Death
- Harmaline
- Harmine
- Iboga
- Ibogaine
- Lysergic Acid Diethylamide (LSD)
- 3,4-Methylenedioxymethamphetamine (MDMA)
- Methylone
- Microdosing
- Monoamine Oxidase Inhibitors (MAOIs)
- Pharmahuasca
- Psilocybin Mushrooms
Therapy & Meditation
- Cognitive Behavioral Therapy (CBT)
- Conscious Leadership Group
- Dialectical Behavior Therapy (DBT)
- Internal Family Systems (IFS)
- Transcendental Meditation (TM)
Technology & AI
- ChatGPT | OpenAI
- Claude | Anthropic
- Claude Code | Anthropic
- Oboe
- Procreate
- Quantified Self
- Roost Laptop Stand
- X
- YouTube
Business
Fitness & Movement
- Golgi Tendon Reflex
- GymnasticBodies
- The Happy Body Program
- Pectoralis Minor
- Total Immersion Swimming
Birds
People
- Peter Attia
- Diana Chapman
- James Clear
- Sean Connery
- Dominic D’Agostino
- Edward de Bono
- Anthony de Mello
- Peter Drucker
- Roland Griffiths
- Sam Harris
- Gay Hendricks
- Katie Hendricks
- Danny Hillis
- Sami Inkinen
- Hugh Jackman
- Billy Joel
- Kevin Kelly
- Richard Koch
- Terry Laughlin
- Mike Maples Jr.
- Terence McKenna
- Hamilton Morris
- Dustin Moskovitz
- Casey Neistat
- Chuck Nichols
- Chris Palmer
- Rhonda Patrick
- Kevin Ryan
- Richard Schwartz
- Christopher Sommer
- Studs Terkel
- Gary Wolf
- Tommy Wood
Timestamps
- [00:00:00] Start.
- [00:01:59] What I’m doing to help prevent Alzheimer’s: sauna, Norwegian 4×4 intervals, Zone 2, urolithin A, lithium orotate, and dental health.
- [00:06:46] Knowing what keeps you stuck and still not changing: IFS, CBT, DBT, and the cost of inaction.
- [00:11:26] Will I move to a looser, more extemporaneous format? (Send me your ideas.)
- [00:17:51] From intellectual collector to builder.
- [00:18:38] What we’ll wish we’d been doing with AI 12 months from now.
- [00:19:05] Staying hopeful as the news gets darker: social media fasts, upside time vs. downside time, and Hard Times.
- [00:27:19] Will handmade work and human imperfection become more valuable?
- [00:27:37] Fix your state: exercise.
- [00:27:58] The best way to spend 5K–10K to get current on AI (you don’t need to).
- [00:29:59] Where psychedelics fit for me now, shorter-acting compounds, and anti-inflammatory effects at tiny doses.
- [00:33:49] Hugh Jackman’s 2,000-meter row.
- [00:37:17] What Quantified Self 2.0 would need to show me, and the missing piece of behavior change.
- [00:43:26] Life before and after psychedelics, and losing the fear of death.
- [00:49:59] “All-natural” vs. synthetic: supplements, cholesterol, and being your own advocate.
- [00:58:02] Xylitol and white teeth.
- [01:00:22] What I still love doing inefficiently.
- [01:00:59] Preventing tech neck.
- [01:03:05] Minimum effective dose for flexibility.
- [01:04:39] The $20 tip from Billy Joel.
- [01:06:09] My favorite birds.
- [01:07:12] When to keep investing in a friendship.
- [01:08:09] Am I at peace?
- [01:09:20] Parting thoughts.
Want to hear more about getting unstuck and rebuilding personal agency? Listen to part one of this Q&A, in which I discussed The 4-Hour Workweek in the age of AI, revisiting old advice as your life changes, rebuilding momentum with small daily actions, knowing when to persist and when to quit, investing 10 times more in health and relationships, making room for serendipity, state, story, and strategy for answering questions well, accelerated TMS, The 4-Hour Body after 40, and much more.
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This episode is brought to you by Shopify! Shopify is one of my favorite platforms and one of my favorite companies. Shopify is designed for anyone to sell anywhere, giving entrepreneurs the resources once reserved for big business. In no time flat, you can have a great-looking online store that brings your ideas to life, and you can have the tools to manage your day-to-day and drive sales. Go to Shopify.com/Tim to sign up for a one-dollar-per-month trial period. It’s a great deal for a great service, so I encourage you to check it out. Take your business to the next level today by visiting Shopify.com/Tim.
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