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Tim Ferriss

Dom D'Agostino on Disease Prevention, Cancer, and Living Longer (#188)

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dominic d'agostino

“The pursuit of size and strength really contradicts what we want to go after for longevity.” – Dominic D’Agostino

Dr. Dominic “Dom” D’Agostino (@DominicDAgosti2) is one of my most popular guests, and I’m happy to have him rejoin the show for the third time. (You can listen to Dom’s first appearance here, and his second appearance here).

Dom is an assistant professor in the Department of Molecular Pharmacology and Physiology at the University of South Florida Morsani College of Medicine, and a senior research scientist at the Institute for Human and Machine Cognition (IHMC) — which is mentioned in the current issue of Outside Magazine (on which there’s a clown who looks a lot like me).

Much of Dom’s work is related to metabolic therapies and nutritional strategies for peak performance and resilience in extreme environments. Dom’s research is supported by the Office of Naval Research (ONR), Department of Defense (DoD), and other private organizations and foundations.

In this episode, Dom focuses on disease prevention, cancer, and more mastery of the ketogenic diet. Please enjoy this tutorial and masterclass with Dominic D’Agostino.

You can find the transcript of this episode here. Transcripts of all episodes can be found here.

#188: Dom D'Agostino on Disease Prevention, Cancer, and Living Longer

Want to hear my first interview with Dom D’Agostino? — Listen to our in-depth conversation here. In this episode, we discuss fasting, heavy deadlifts, and the end of cancer (stream below or right-click here to download):

#117: Dom D'Agostino on Fasting, Ketosis, and The End of Cancer

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QUESTION(S) OF THE DAY: What was your favorite quote or lesson from this episode? Please let me know in the comments.

Scroll below for links and show notes…

Selected Links from the Episode

  • Connect with Dom D’Agostino:

KetoNutrition.org | Facebook | Twitter | University of South Florida

Show Notes

  • Does the ketogenic diet “beat” chemotherapy for cancer? [06:45]
  • Dom elaborates on the detoxifying effects of ketosis on precancerous cells in healthy individuals. [15:07]
  • How does one jump start a daily ketogenic cycle without supplements? [16:25]
  • How can lean muscle mass be maintained when fasting? [17:56]
  • What types of cancers are most affected by ketosis? [21:34]
  • What process is most effective for targeting cancer? [23:25]
  • The ketogenic diet as a do no harm therapy. [26:14]
  • Nutritional ketosis and hyperbaric oxygen therapy: how, why, and when? [27:51]
  • How long would an amateur endurance athlete need to be in ketosis to get the full benefit of being fat adapted for a marathon, and what supplement stack would Dom recommend? [33:47]
  • Should an APOE4 (Apolipoprotein E) carrier — someone at genetic risk for Alzheimer’s disease — be careful with a ketogenic diet? [36:35]
  • Are there any downsides to shifting out of ketosis for an occasional cheat meal? [41:06]
  • What does Dom have to say about the study that found ketogenic diets have no metabolic advantage? [46:19]
  • If your body doesn’t do well with dairy or nuts, what would be good fat source alternatives on a modified ketogenic diet? [48:58]
  • Dom talks about Metformin, methylene blue, and other non-food substances meant to increase longevity. [50:24]
  • Can the ketogenic diet be used while glycolytic training? [58:06]
  • What is it like for Dom to be an academic who makes serious weight training a big part of his life, and how do these two pursuits complement (or complicate) each other? [1:01:06]
  • Dom’s thoughts on John Kiefer’s carb backloading. [1:07:26]
  • Are ketone salt products on the market safe — specifically the DL beta-Hydroxybutyric salts? [1:12:27]

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