The Psychedelic News Hour: New Breakthroughs, Compound Comparisons and Warnings (Psilocybin/LSD/Ayahuasca/N,N-DMT/5-MeO-DMT), Treatment of Trauma, Scalable vs. Unscalable Approaches, Making Sense of “Bad” Trips, and Much More (#458)

Tim Ferriss
Photo by Todd White

Welcome to another episode of The Tim Ferriss Show, where it is normally my job to deconstruct world-class performers of various types, of all ilks.

In this special episode, the tables are turned. Instead of interviewing someone else, I am interviewed by two experts on several topics I’ve both studied and supported, including psychedelic-assisted psychotherapy and what it can do to heal trauma and—broadly speaking—possible futures for mental health. This audio was recorded on a new show, The Psychedelic News Hour, soon to be a podcast, and I’m in conversation with two people: David Rabin, MD, PhD, (@drdavidrabin), a board-certified psychiatrist and neuroscientist, executive director of The Board of Medicine, and co-founder of Apollo Neuroscience, and Molly Maloof, MD, (, a physician, Stanford lecturer, and ketamine-assisted psychotherapist.

This episode was recorded on Clubhouse, an app still in private beta and defined by their tagline: “Clubhouse is a space for casual, drop-in audio conversations—with friends and other interesting people around the world.” 

One final note: I recorded this on my phone, a necessity for using the app, so the audio quality isn’t studio quality, but it was polished as much as possible. Thank you for understanding, and thanks to everyone who joined and asked thoughtful questions. 

Please enjoy!

Listen to the episode on Apple Podcasts, Spotify, Overcast, Stitcher, Castbox, Google Podcasts, or on your favorite podcast platform.

This episode is brought to you by the book How to Lead by David Rubenstein.

The transcript of this episode can be found here. Transcripts of all episodes can be found here.

#458: The Psychedelic News Hour: New Breakthroughs, Compound Comparisons and Warnings (Psilocybin/LSD/Ayahuasca/N,N-DMT/5-MeO-DMT), Treatment of Trauma, Scalable vs. Unscalable Approaches, Making Sense of “Bad” Trips, and Much More

This episode is brought to you by the book How to Lead by David Rubenstein. David Rubenstein is one of the visionary founders of The Carlyle Group and host of The David Rubenstein Show, where he speaks to leaders from every walk of life about who they are, how they define “success,” and what it means to lead. Jeff Bezos, Richard Branson, Warren Buffet, Bill Gates, Ruth Bader Ginsburg, Phil Knight, Oprah—all of them and more—are featured in his new book, titled How to Lead. This comprehensive leadership playbook illustrates the principles and guiding philosophies of the world’s greatest game changers. In its pages, you can discover the experts’ secrets to being effective and innovative leaders. 

Past podcast guest Walter Isaacson had this to say: “Reading this invaluable trove of advice from the greatest leaders of our time is like sitting in an armchair and listening to the masters reveal their secrets.” Pick up a copy of How to Lead: Wisdom from the World’s Greatest CEOs, Founders, and Game Changers by David Rubinstein in hardcover, ebook, or audio anywhere books are sold. 

What was your favorite quote or lesson from this episode? Please let me know in the comments.


Want to hear another podcast discussing psychedelics?  Listen to my conversation with Rick Doblin, the founder and executive director of the Multidisciplinary Association for Psychedelic Studies (MAPS). 

#440: Rick Doblin — The Psychedelic Domino That Tips All Others


The Tim Ferriss Show is one of the most popular podcasts in the world with more than 900 million downloads. It has been selected for "Best of Apple Podcasts" three times, it is often the #1 interview podcast across all of Apple Podcasts, and it's been ranked #1 out of 400,000+ podcasts on many occasions. To listen to any of the past episodes for free, check out this page.

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5 Replies to “The Psychedelic News Hour: New Breakthroughs, Compound Comparisons and Warnings (Psilocybin/LSD/Ayahuasca/N,N-DMT/5-MeO-DMT), Treatment of Trauma, Scalable vs. Unscalable Approaches, Making Sense of “Bad” Trips, and Much More (#458)”

  1. Great content and willingness to take deeper dive. I can definitely appreciate the courage it takes to look inward not knowing what may come up. Much like we do in our Work you will be watching in the documentary titled “The Work”. The topics you are bringing to the light of day saved the lives of so many of us in Folsom prison and continues to do so today. Thank you my brother. Eldra A.K.A. Vegas.

  2. Tim, this is in reply to your 4 September 5-bullet Friday email, not to this podcast episode.
    I’ve been a regular user of Berkey filters in the past, however I do not regularly use them now. There is a problem with the design that, far as I know, has not been addressed.

    When installing the filters into the assembly, you’ll notice that the threads and the wing nuts are plastic and there is no locking portion of the nut. When pouring water into the upper chamber it often causes the assembly to shake and vibrate, which loosens the wing nuts over time. When this happens, the seal on the upper chamber begins to weaken (as it’s created by the pressure from the wing nuts being tightened), and you get a leak of the unfiltered water into the lower chamber. This is impossible to detect without removing the upper chamber from the assembly, and even then slight seepage would be difficult to detect. The threading is too course to use a thread locker, and other methods of securing the wing nuts would permanently affix them, making it very difficult to change the filters in the future. Basically, you have to constantly check to make sure that the wing nuts are still tight, which means re-tightening them frequently.

    Now besides that being a pain, the constant loosening and re-tightening weakens the threads (remember, they’re plastic), and eventually they break, well before the 6,000-gallon point. Once the threads are broken, the filters are useless and need to be replaced. I found I was replacing filters every 800-1,000 gallons. At this point, with the cost of replacing filters and the pain in the ass of doing this all the time, plus the risk of contaminants bypassing the filter, I’ve found it’s better (easier and more cost effective, break even after just a year or two depending on use patterns) to have a residential water filtration system professionally installed.

    The Berkeys could possibly still be good for emergency use, but daily use for me unfortunately is out of the question. Also unfortunately because the Berkey filters require back-flushing with potable water prior to first use, storing a Berkey for emergencies doesn’t make much sense unless you have some other way of pressurizing potable water (I’m assuming the emergency means your tap water is contaminated and/or not running) OR you do this prior to storing the Berkey; unfortunately *again* though, most people when they get the Berkey for emergency use simply put the box in the pantry and forget about it, then it’s unsafe/unusable when they have no way of back-flushing the filters.

  3. Hey Tim,

    You mentioned you do not invest in this space to avoid conflicts of interest. If you did invest, what companies would you be investing in?

  4. David, Molly, Tim and Team Tim Ferriss,

    Words cannot express my gratitude for bringing awareness to the topic of mental health, HRV, and traumatic stress. It is incredible to watch each step along the journey and to clearly understand the risks and warnings of using psychedelics. Helping one person can most certainly change the world and have a butterfly effect!

    At the end of the podcast, there was mention about a list of opportunities to invest in projects:

    a) where might one find information for such opportunities, and
    b) is it possible for investments to be open to non-accredited investors (e.g. via Seedinvest, Startengine, Wefunder, etc.?

    Unus pro omnibus, omnes pro uno!

  5. I enjoyed this episode very much. I’ll also take a moment to send warm wishes after the recent childhood abuse episode. You’re doing good work. Thank you.

    Podcast guest suggestion n the the optic of leverage mentioned here and the episode on wolf reintroduction/conservation (a small amount of effort/money for a huge potential effect)

    A Tim Ferriss podcast interview with Rob Hopkins would provides another opportunity for just such leverage. Rob is a grassroots environmentalist who creates, catalyses and curates genuine positive change transforming towns and communities through imagination, storytelling and action.

    Rob fits with Tim’s personal transition from performance to meaningful, compassionate and generative action. I have read some books, otherwise I have no personal connection.

    Not a famous businessman, athlete or actor but well worthwhile. I hope this will filter to the right place.

    be well.