The Random Show — The 2–2–2 Rule, The Future of AI, Bioelectric Medicine, Surviving Modern Dating, The Promises of DORAs for Alzheimer’s, and Wisdom from Anthony de Mello ( #838)

Welcome to another wide-ranging “Random Show” episode that I recorded with my close friend Kevin Rose (digg.com)!

We explore the promises of DORAs for Alzheimer’s, Kevin’s AI stack and where AI is heading, the challenges of modern dating, wisdom from Anthony de Mello, bioelectric medicine, and much, much more.

Please enjoy!

This episode is brought to you by:

• Qlosi prescription eye drop used to treat age-related blurry near vision (presbyopia) in adults
• David Protein Bars with 28g of protein, 150 calories, and 0g of sugar
• Eight Sleep Pod Cover 5 sleeping solution for dynamic cooling and heating
• Coyote the card game​, which I co-created with Exploding Kittens

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Transcripts

• This episode
• All episodes

SELECTED LINKS FROM THE EPISODE

• Connect with Kevin Rose:

Website | Instagram | Twitter | Threads | Bluesky | Digg.com | Diggnation Podcast

Frameworks and Rules to Apply

• Kevin’s 2-2-2 Rule for Alcohol: 2 drinks max in one day, 2 days a week, never 2 days in a row.
• Nonviolent Communication
• Terry Real’s Relationship Repair Frameworks

Books

• Awareness: Conversations with the Masters by Anthony de Mello
• The End of Alzheimer’s: The First Program to Prevent and Reverse Cognitive Decline by Dale Bredesen
• Fierce Intimacy: Standing Up to One Another with Love by Terry Real
• Gold by Rumi; trans. Haleh Liza Gafori
• The Mind of a Mnemonist: A Little Book about a Vast Memory by A.R. Luria
• The New Rules of Marriage: What You Need to Know to Make Love Work by Terry Real
• Nonviolent Communication: A Language of Life by Marshall Rosenberg
• Searching for Bobby Fischer: The Father of a Prodigy Observes the World of Chess by Fred Waitzkin
• Stop Fixing Yourself: Wake Up, All Is Well by Anthony de Mello
• Tomorrow, and Tomorrow, and Tomorrow: A Novel by Gabrielle Zevin
• Why We Sleep: Unlocking the Power of Sleep and Dreams by Matthew Walker

Films

• Bad News Bears
• Fantasia
• The Outsiders
• Searching for Bobby Fischer

Apps, Courses, and Digital Tools

• ChatGPT
• Claude (Haiku, Sonnet)
• Gemini
• NotebookLM (Google)
• Notion + Notion AI
• Oboe
• Perplexity
• The Way App

Conditions, Therapies, Drugs, and Protocols

• Alzheimer’s Genes (e.g., APOE variants)
• Ambien (Zolpidem)
• Aphantasia
• Belsomra (Suvorexant)
• BrainsWay TMS Systems
• D-cycloserine (DCS)
• Dual Orexin Receptor Antagonists (DORAs)
• Exogenous Ketones
• GLP-1 Agonists (e.g., Tirzepatide, Mounjaro, Ozempic)
• Hyperphantasia
• Ketogenic Diet
• MagVenture TMS Systems
• p-tau Blood Tests for Alzheimer’s Risk
• Rapamycin
• Resting-State fMRI–Guided TMS Targeting
• Synesthesia
• Trazodone

Fitness, Recovery, and Movement Gear

• Due North Rubz Ball Foot Massager
• Oura Ring
• TANK M3 Push Sled by Torque Fitness
• Tune Up Fitness Alpha Ball
• Pacerocker Walking Pad Treadmill

Kitchen and Home

• AXTH 25-in-1 Small Precision Screwdriver Set
• Caledonia Spirits Barr Hill Gin
• Maestri House Rechargeable Milk Frother

Recording Gear

• Elgato Wave:3 USB Microphone

Toys, Games, and Hobbies

• Coyote Card Game
• Nanoblock Bonsai Tree Assortment

AI / Tech Stack and Companies

• AMD GPUs
• Amazon Data Centers
• Android
• AWS (Amazon Web Services)
• Basecamp
• Google Cloud
• Google TPUs
• Microsoft Azure
• Nothing Earbuds with AI Talk Button
• Nothing Phone
• NVIDIA GPUs
• Salesforce
• Sandbar

People

• Peter Attia
• David Baszucki
• Jan Ellison Baszucki
• Marc Benioff
• Dale Bredesen
• Ed Coan
• Anthony de Mello
• Jack Dorsey
• Molly Ferriss
• Jason Fried
• Haleh Liza Gafori
• Kevin Kelly
• A.R. Luria
• Rhonda Patrick
• Terry Real
• Darya Rose
• Toaster Pino Rose
• Marshall B. Rosenberg
• Rumi
• Chris Sacca
• Henry Shukman
• Kevin Tracey
• Joshua Waitzkin
• Matthew Walker
• Nolan Williams
• Gabrielle Zevin

Organizations

• Baszucki Group
• Metabolic Mind
• Saisei Foundation

Referenced and Related Podcast Episodes

• The Random Show: Ketones for Cognition, Tim’s Best Lab Results in 10+ Years, How Kevin Hit 100 Days Sober, Home Defense, Vibe Coding Unleashed, and More | The Tim Ferriss Show
• What Most Has My Attention Right Now: Credible (vs. Bogus) Vagus Nerve Stimulation | The Tim Ferriss Show
• Nolan Williams: A Glimpse of the Future—Electroceuticals for 70%–90% Remission of Depression, Brain Stimulation for Sports Performance, and De-risking Ibogaine for TBI/PTSD | The Tim Ferriss Show
• Live-Action Zelda, and the Spank Bank Declines Charges | Diggnation
• The Tim Ferriss Podcast Is Live! Here Are Episodes 1 and 2 | The Tim Ferriss Show
• Dr. Matthew Walker, All Things Sleep: How to Improve Sleep, How Sleep Ties into Alzheimer’s Disease and Weight Gain, and How Medications, Caffeine, THC/CBD, Psychedelics, Exercise, Smart Drugs, Fasting, and More Affect Sleep | The Tim Ferriss Show
• Can a Sleeping Pill Help Fight Alzheimer’s? | The Matt Walker Podcast
• David Baszucki, Co-Founder of Roblox: The Path to 150M+ Daily Users, Critical Business Decisions, Ketogenic Therapy for Brain Health, Daily Routines, the Roblox Economy, and More | The Tim Ferriss Show
• Kevin Kelly: Excellent Advice for Living | The Tim Ferriss Show

Timestamps:

• [00:00:00] Start.
• [00:00:52] Why Kevin concluded nearly seven months of sobriety, and the 2-2-2 Rule he now follows for alcohol consumption.
• [00:07:12] My recent adventures in accelerated TMS and bioelectric medicine.
• [00:21:09] The tragic death of Nolan Williams and funding future research through the Saisei Foundation.
• [00:24:23] Aphantasia vs. hyperphantasia, and Joshua Waitzkin’s ability to “feel” chess.
• [00:33:12] DORAs for sleep and Alzheimer’s prevention: Matt Walker, Belsomra, and the terrifying p-tau blood test.
• [00:41:21] Dale Bredesen’s kitchen-sink approach to dementia and the ketogenic connection.
• [00:46:22] The rapid pace of AI development: Why your opinion from three months ago is already obsolete.
• [00:49:40] Google’s full-stack advantage: TPUs, Gemini 3, and why they were built for this moment.
• [00:52:50] The future of venture capital: Seed rounds shift later as entrepreneurs gain leverage.
• [00:58:05] Kevin’s three AI investment buckets: Power, data centers, and bloated companies ripe for automation.
• [01:02:05] Holiday gift ideas and recommended reading.
• [01:17:41] The Way App and meditation with Zen master Henry Shukman.
• [01:21:44] Kevin’s AI stack: Nothing earbuds, Sandbar ring, Notion AI, and the NotebookLM podcast hack.
• [01:26:58] Oboe.fyi: The AI learning platform and my investment philosophy.
• [01:32:09] My new girlfriend, the perils of modern dating apps, and building a communication toolkit.
• [01:38:17] Terry Real’s relationship wisdom: Why objective reality has no place in an argument.
• [01:47:18] Dog updates: Molly, a new puppy, and Toaster on rapamycin.
• [01:47:58] Parting thoughts and happy holidays.

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This episode is brought to you by Qlosi, an FDA-approved, prescription eye drop designed to improve your near vision and help you see things up close more clearly. With once- or twice-daily dosing, packaged in single-dose vials, Qlosi fits into your routine and is ready when you need it. In clinical studies, people could read letters in the eye chart equivalent to reading menus, recipes, and phone screens with fast acting, near-vision improvement often starting in just 20 minutes. Most side effects in studies were mild and short-lived, including eye discomfort and headaches. Give your readers a break and ask your eye doctor if Qlosi is right for you. Visit Qlosi.com/Tim to find an eye doctor, along with full prescribing information.

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Want to hear another episode where Kevin and I let our random flag fly? Listen to our conversation here, in which we discussed Kevin’s journey to 100 days sober, my best lab results in 10+ years from ketogenic diet and intermittent fasting, the vibe coding revolution transforming $250k projects into $50 experiments, home defense and security, GLP-1 agonists, the future of venture capital in an AI-driven landscape, and much more.