The Tim Ferriss Show: Dr. Rhonda Patrick on Life Extension, Performance, and Much More (#12)

Dr. Rhonda Patrick
Dr. Rhonda Patrick

This episode of The Tim Ferriss Show is sponsored by Bluehost, which I used for my first WordPress blog, and I still use them for sites today. Click here for a special offer!

Now, on to our guest…

My guest this episode is Rhonda Perciavalle Patrick, Ph.D., who works with Dr. Bruce Ames, the 23rd most-cited scientist across ALL fields between 1973 and 1984 (!).

Dr. Patrick also conducts clinical trials, performed aging research at Salk Institute for Biological Studies, and did graduate research at St. Jude Children’s Research Hospital, where she focused on cancer, mitochondrial metabolism, and apoptosis.

What does that all mean? Time is precious, right? Long podcast needs to be worth it, right? Here you go…

Whether you want to extend life, inexpensively buy a stem-cell “insurance policy” (hint: related to the Tooth Fairy), or guard against cancer, she will have a surprise insight for you.

In this episode, we cover a lot:

  • Are there simple methods for extending lifespan? What looks most promising?
  • What are the easiest ways to minimize your risk of cancer?
  • What are the dangers of taking certain common supplements? What’s worth it and what isn’t?
  • How can diet change the expression of your genes? How can this can be passed on to offspring?

…and much more.

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Ep. 12: Dr. Rhonda Patrick on Life Extension, Performance, and More

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Show notes and links are below, and please find Rhonda on Twitter to say hello or ask questions. She’s very responsive.


You can find the transcript of this episode here. Transcripts of all episodes can be found here.

Select Links and Resources for Episode 12


George Carlin –

Dr. Bruce Ames –

St. Jude’s donation link –

Bluehost offers –

Wellness FX –

Vitamix 5200 Blender –

National Dental Pulp Laboratory –

Dr. Rhonda Patrick’s homepage –

Rhonda on Twitter – @foundmyfitness

Rhonda on Facebook –


Nutrition and Physical Degeneration – Weston Price

Wild Fermentation – Sandor Katz and Sally Fallon

Spark – Eric Hagerman

The Paleo Solution – Robb Wolf

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The Tim Ferriss Show is one of the most popular podcasts in the world with more than 900 million downloads. It has been selected for "Best of Apple Podcasts" three times, it is often the #1 interview podcast across all of Apple Podcasts, and it's been ranked #1 out of 400,000+ podcasts on many occasions. To listen to any of the past episodes for free, check out this page.

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91 Replies to “The Tim Ferriss Show: Dr. Rhonda Patrick on Life Extension, Performance, and Much More (#12)”

  1. I think I lost where the thread was, but did want to comment on the fact that I have lost 4 lbs, and 3 inches. I am building muscle in my legs like crazy, just hiking uphill for about 30 min. then down again. I eat protein mostly, well, almost as many vegies,

    Olive oil, real butter, half and half for my 2 cups of coffee in the a.m. and I do use Stevia. I don’t measure, or weigh my food anymore, I drink about 4 of the 8 ounces of water per day, sometimes more. I eat about 3 times a day, and nothing in between because I drink water, and I am not getting hungry.

    I have lost the 4 lbs in about 4 weeks, so not as fast, but I never planned to shoot for that. My plan was to “get active” and eat good food. I did drop all white rice, and pasta, I don’t eat brown rice either. First few days I felt way hungry, then it just discipated. Ok, so I will try to keep you guys posted. I like the more protein, and nuts about the vegies. A snack I made the other day sort of “with” dinner, was celery, Adams crunchy, and raisins;)

    I’ve also had a burger with bun and all the fixins on the barby, and baked a pie for the gathering as well, I didn’t have a little piece, I had a big one, still losing lbs, and most important, inches, Denise

  2. I haven’t had the chance to listen to this yet as on a holiday and must seem sociable… But looking forward to getting back and having a couple hopefully to go through! Just wanted to say, as you asked for feedback, that I’m loving these podcasts and I really hope you keep doing them. I’ve been inspired a ton by a bunch of them already and they’re always fascinating and entertaining. Washing the dishes is now a much more pleasant task… thanks! (I don’t normally leave comments like this so this is a testament to the quality and how much they’re appreciated!)

  3. Awesome show!! Keep the shows coming, your shows have so many great tips and websites to go too..

    1. If your piss is smelly after you eat asparagus you know you have a MTHFR polymorphism. As Tim explains in the 4-hour body, if your piss does smell you cannot use high dose IV vitamin C for astounding tissue repair and cancer prevention.

      1. Really? I thought everyone pissed smelly after eating asparagus. Yes, I get strong smell. I will have a look in 4HB. Thanks Adam.

      2. I did not find it in the 4 HB book. Do you remember the chapter where he mentions mthfr? Thanks!

      3. I’d like to see the literature on this, I don’t know anyone who’s urine doesn’t smell after eating asparagus.

  4. Wow Tim! Forget the show notes on this one. I need a translator! You made my brain hurt! I love the podcast but this one skipped over my tiny brain. And then its good unless its bad. Its bad unless its good. Its bad but maybe good later. NO NO NO! I like the ones that say do this then this and never this. That makes me happy! After listening to this episode I had to goto my happy place. Please don’t think this is a bad review of the show or anything you are doing, (besides eating bugs!)I really enjoy hearing what you have to say and learning from you. So, thanks for the great stuff you put out with the podcast, the books, the blog and everything else.

  5. Good show! I like the difference in getting a researcher instead of a self promoter….not the finite answer, but the nuanced one. Keep them coming!

  6. Thanks for this episode. Please consider allowing direct download of the mp3 file from your site or from the non-iTunes RSS feed, thanks!

  7. Excellent show! Rhonda is brilliant!! More of this type of content would be great. In fact, please bring back Rhonda for more. You could do an entire series of topics with her I would bet.

  8. I wonder how often Rhonda gets to talk shop outside of work for conversation.. loved this podcast. I agree with a researcher vs someone who has somethg to sell. u can tell Rhonda enjoys what she does.


    keep the shorts coming… I love the 29min pods… perfect for my short 30min runs!

  9. Been following Dr. Patrick’s guest podcast. awesome ! the Joe Rogan stuff is just great. I can just listen to her all day long. just info. no self promotion. more of her please. also, if you can ask her next time to comment on “Fasting Might Regenerate Human Immune System” by Valter Longo from Universtity of Southern California.

  10. [2:50] How did Tim and Rhonda first connect?

    [4:40] Rhonda’s Guinness World Record

    [6:00] Rhonda’s scientific career

    [7:20] Bringing “real” science to clinical research

    [9:35] What is translational research?

    [11:00] What are the causes of micronutrient inadequacies/deficiencies?

    [16:45] What would Rhonda suggest consuming for Vitamin K?

    [18:00] What does Rhonda’s diet currently look like?

    [21:40] Where does Rhonda stand on supplementation?

    [27:20] What to do about microscopic cancer a.k.a. pre-cancer

    [31:00] Benefits and disadvantages of IGF-1

    [35:20] Is life extension a trade-off between quantity and quality, or can you get the best of both worlds?

    [39:20] The biochemical and genetic profiles of high protein, moderate-to-low fat, moderate-to-low carbohydrate versus high fat, low carbohydrate, moderate protein diets

    [41:50] What is methylation?

    [48:25] Epigenetics can be affected by stress, diet and exercise

    [51:50] Research suggests that methylation patterns in humans correlate to chronological age (+/- 4 years accuracy)

    [56:05] How do you harvest and bank stem cells for later use?

    [01:01:10] Difference between the modifiers mesenchymal and pluripotent

    [01:09:45] Besides stem cell storage, what else can be done to potentially extend healthful lifespan?

    [01:12:25] The absence of bad things does not guarantee the presence of good things – why Tim suggests making one small change at a time to one’s eating habits

    [01:15:10] Why Tim is a proponent of eating legumes

  11. First lady guest on the show, excellent! I was a bit surprised at the censoring of swear words, I don’t mind it either way, but is it just for this episode or will this be the format going forward? The breaks kinda interrupt the flow of the show, but if it’s to keep it non-explicit I understand.

  12. Hi Tim,

    Very cool episode. Probably one of my favorites so far. It was good to get back into the weeds again. It went into a lot of topics near and dear to my heart. It brought me back to P450 cytochrome for drug metabolism research project I worked on as an undergrad. (Please note: I was just a lab bitch)

    I am also now going to look into saving the stem cells for my unborn daughter. Great work and looking forward to your next episode. Keep them coming.

  13. Thanks for another amazing episode – most fascinating yet!

    Do you have a recommendation for where to get smoothie recipes for what was discussed here? Does Rhonda have her favorite online somewhere? Do you?

      1. Hi Rhonda,

        I left a comment on your blog post. This seems like a lot of calories. I came up with 800+ without the protein powder. Does this seem right? Thanks!

      2. In Tim’s podcast you mentioned you sometimes add protein and glutamine. I am wondering how much you add, and how often you add? Additionally what kind of protein powder do you use. Thanks!

      3. Hi Rhonda Patrick,


        I have a hard time finding rainbow chard leaves in Sweden. We just have the small (same size as baby spinach leaves ) and then I have to use about 1 bag = $3 per smothie.. Could I use rhubarb instead? Or do you have an alternative to rainbow chard?


  14. Note to Tim and/or warning:

    *Followed SCD 2 years. Works perfectly – except for one thing.

    Developed a weird deficiency of something that caused a lot of problems – diminishing testosterone, retinol toxicity, diminished detoxification & liver function, increased oxidative stress, and similar symptoms.

    *Turns out: I can’t follow SCD without including either L-Cysteine, or L-cysteine-rich protein sources (Dairy, Whey protein).

    Cysteine only occurs in dairy. In other cases, it’s biosynthesized from L-cystine, which occurs in all complete protein sources, but scarcely.

    Cysteine is the precursor of Glutathione (kind of important!), and is actually a required cofactor many, many many mineral-enzymes (CYP, among others).

    1. Thank you for this posting this comment. I am also following SCD in combination with paleo and appreciate knowing of your experience.

      1. The addition of L-cysteine was literally life-changing for me.

        My last testosterone test, before adding it, was 500 ng/dl (total) – and I was doing everything right! (5% BF, Regular strength gains, IF + SCD + careful inclusion of all minerals and other nutrients)

        I’m about to do one more test, after 2 weeks of doing no other changes than adding L-cysteine it.

  15. Great episode, You brought up a great point, that was never elaborated on and it was a point or conclusion I had come to myself. Which is, there

    seems to be a decision to be made between eating to live longer vs eating to be an athlete/ bodybuilder/ high performer physically. It seems you cant have them both

  16. Thanks for censoring the swear words. It was a nice update to the format. Now I can listen without worrying about my little ones overhearing.

    I’m also enjoying the diversity and the passion behind your guests. It does get hard to follow when the industry lingo comes out, but you’re doing good making it easy for people to understand and catch up.

    Thank you and keep up the good work!!

  17. Excellent show! Will be listening to it more than once. Love your humble, casual interview style and very much enjoyed learning from your guest’s extensive knowlege- she is brilliant and articulate. Also love that you seem to interview guests with a deep passion for what they do and this adds to the pleasure of listening to them.

  18. You are a genius editor in disguise as a management writer…thank you for picking so many diverse topics and getting to the center of each one. Wish I’d invested in Stem Cell technology 🙂


    Spark is actually written by John Ratey with contributions by Eric Hagerman.

  20. Rhonda, what about supplementation with q10? does it really help the mitchondria or is it lost in the gut?

    1. Hi! Oral supplementation of coenzyme Q10 increases plasma, lipoprotein, and blood vessel levels, but it is unclear whether tissue coenzyme Q10 levels are increased, especially in healthy individuals.

      However, Coenzyme Q10 supplementation has resulted in clinical and metabolic improvement in some patients with hereditary mitochondrial disorders (they have low levels of Q10).

      1. Hi Rhonda, can we look for evidence of these hereditary mitochondrial disorders in 23andme/promethease results? I have low levels of COQ10 as identified by spectracell labs and would to know if it is due to hereditary reasons.

  21. Great podcast tim!

    While talking about getting in all these micronutrients like Dr. Patrick suggests, one should not forget that glucose is the most important “micronutrient” to support energy production at a cellular level.

    I’m not convinced that your suggestion of 30 grams of protein in the morning is healthful in any way. Cortisol rises during the night to keep blood sugar stable. Getting in some carbs first in the morning will reduce cortisol and stress. However getting 30g of protein without a lot of carbs is like pouring gasoline on a fire. You will end up with a huge stress response and will – of course – loose weight. Is this a healthy way to loose weight? I don’t think so.

    Maybe you could interview Danny Roddy to get an alternative opinion about the topic of life extension and reconsider some assumptions.

    I hope this wasn’t too rude 😉

  22. This was my favorite episode yet. I’m pissed I didn’t have my wisdom teeth preserved. Now I’m wondering if oral surgeons sell teeth as a back-end biz model : )

  23. I’m surprised that only one commenter mentioned this so far:

    This podcast was too detailed for me and off in the weeds.

    I love your other podcasts, but for the general audience, there were a lot of technical terms thrown around and not enough high-level. I think you tried to reel Rhonda in a couple of times, but she continued answering with all technical terms. Not sure if it was your goal was to have this interview be addressing a very niche science/biology audience, but I would have liked if you asked Rhonda: “So how does the Joe Shmoe interpret all of these studies and details?” There were a few moments where you did this when asking about the morning health-shake or getting Rhonda to explain the definition of epigenetics, but not enough.

    This podcast contrasts with the Mobility WOD guys, who were very easily able to relate many of their “technical” physiology/technical terms to our every-day practical lives.

    1. I almost disagree with this. Mobility WOD talks about functional movements and a lot of stuff superficially; which correlating a muscle action (or something anatomically speaking – e.g., a specific muscle tissue like the quads or the fascia), is a hell of a lot easier to “dumb-down” (per-say) to laymen terms versus when one talks about things at the cellular level. The organism and all of it’s properties are way to vastly complex, and is a reason why Dr. Patrick states throughout the episode that it takes a lot of work to understand it all.

  24. Hey Tim—great episode. Wanted to add my voice to those who are really enjoying the podcast in all its forms, from the 9 minutes to Sam’s essay to the long interviews–they’ve all been great. I’m a strength and lifestyle coach and have always listened to health/fitness shows pretty much exclusively, but I’m making myself branch out with Dave Asprey, Ari Meisel, and you–I’m really enjoying it. Love the Jason Bourne clip at the beginning, too…

    Anyway, thanks and keep it up!

  25. Hi Tim,

    my answer is not about this article. Can i grow taller 1-2 incheswith some techniques? i’m 19 years old

  26. My goodness, Tim. Please, give as a chance to download this as .mp3. Why do i need to stream this? I would rather save to to my cellphone sdcard and listen to it offline.

    1. if you have an android device, please download a podcast player like podcast republic.and you will be able to save the file as a podcast on your device!

  27. Is there any way there will be a transcript of this podcast? This would be epic in Evernote for referring to in the future.

  28. Although i’m sure you have scientific evidence to say that ejaculation leads to shortened lifespan, I’m not sure in the grand scheme of things it really changes anything. If you’re “happy”, then hapiness should have a much higher impact on lifespan then the negative impact of ejaculation, i guess.

    I read a few interesting, “non-technical” but still empirical books about health and aging and one of them in particular, “The Blue Zones” by Dan Buettner comes to mind. In it, he is sent by the National Geographic to find the hotspots in the world where there is the highest proportion of centenarians in the populations and then meet them and try to learn about their lifestyle, food, social life, environment, etc and there are a few clear markers that make people live much longer than others and most of them are not food itself.

    To live longer, from my searches, i would prioritize those 2 first (real list from the book follows):

    1- the WILL to live. Although it might sound strange, i think that most people don’t “want to live” but rather they “want not to die” and that makes a huge difference in life expectancy.

    2- a REASON to go on. Most north american (and people i know that are 60+ yrs old) just have no plans, no measurable goals, and just seem like they are waiting to die. They retire then do nothing. People that lived 100+ yrs in the study wanted something, for example a project to finish, a grand children to take care of and make sure they do well in school, etc.

    Here are the official list from the survey of the ppl that live the longest (the book might be worth a look if you’re interested in that) (#5 & 6 might please you Tim 😉 ):

    1- Move Naturally The world’s longest-lived people don’t pump iron or run marathons. Instead, their environments nudge them into moving without thinking about it.

    2- Purpose Why do you wake up in the morning? Knowing your sense of purpose is worth up to seven years of extra life expectancy.

    3- Down Shift Stress leads to chronic inflammation, associated with every major age-related disease. The world’s longest-lived people have routines to shed that stress.

    4- 80% Rule “Hara hachi bu” – the Okinawans say this mantra before meals as a reminder to stop eating when their stomachs are 80 percent full.

    5- Plant Slant The cornerstone of most centenarian diets? Beans. They typically eat meat—mostly pork—only five times per month.

    6- Wine @ 5 Moderate drinkers outlive non-drinkers, especially if they share those drinks with friends.

    7- Belong Attending faith-based services four times per month – no matter the denomination – adds up to 14 years of life expectancy.

    8- Loved Ones First Centenarians put their families first. They keep aging parents and grandparents nearby, commit to a life partner and invest in their children.

    9- Right Tribe They world’s longest lived people chose or were born into social circles that support healthy behaviors.

    Of course some of these can me slightly modified (change “faith” for hapiness or spirituality and #1 you can probably move more (aka train) if your food nutrient density matches the change. Don’t forget that the people that are 100+ yrs old now were born 100 yrs ago and had a very different mindset and life, so let’s “adjust” a bit)

    Would appreciate similar books suggestion if any; hopes this helps!


  29. i have been looping this podcast for 4 or so hours…and i decided to post a few very personal questions…sorry for the inconvienience…is the information in the podcast applicable for ligament regeneration or repair…what could be the cause for FREQUENT LIGAMENT TEARS and weak ligaments? Lack of mironutrients?a dysmorphism of a Gene? an acute deficiency ? where is it possible to get this tested? for example in a country like India? By the way Mr. Tim Ferris – I am a huge fan ! i have been closely following your work and trying out a few things here and there as possible and they are all amazing…!i don’t know what the rational , logical person in me would have done but given up if you hadn’t come along!!! 🙂

  30. Thanks for this one and also Ep. 13 which hasn’t its post, but is great and can be well combined to Ep. 6 and 9.

  31. PLEASE PLEASE bring Rhonda back so we can start doing more of her research/advice in the practical via nutrition. there was a TON of intelligence here but I would love to see Rhonda come back WOW! and loved the format, loved what you’re delivering in this podcast. just brilliant.

  32. I’m taking Molecular Genetics right now at Binghamton University, and we’re learning most of the stuff you guys were talking about. Small world.

  33. Thanks Tim and Dr. Rhonda this was very useful info.

    I have a question I remember recently listening once before to this very interview where Tim spoke on the topic of how avoiding ejaculation can prolong longevity and for some reason I’m having a hard time finding that point of the conversation, can someone please direct me if you have a clue?

    Also Dr. Rhonda my question to you is I know vitamin C is extremely sensitive to perishing in the presence of light, oxygen and heat so I was wondering does fermentation preserve the vitamin c content and to what extent and does fermentation increase the bio-availability of vitamin C?

    I’m looking forward to hearing the next interview with her.

  34. I really liked this Podcast! Had to rewind several times because of the big words lol…

    I have one question.. what is your take on Glucosamine… I have read the 4HB and its not mentioned at all… Do you think its beneficial or would you recommend another supplement that will address joint pains? (I do workout regularly)


  35. Finally got around to listening to this podcast and it’s terrific. You and Dr. Patrick should plan to talk every year around the same time for as long as possible, to keep comparing notes on both research and personal findings on aging.

  36. Loved this one, Tim! The engineer in me loved the detail! The episode has motivated me to get back into the green smoothies!

    Thanks for sharing some more amazing content!

  37. Listening to these out of order so perhaps this has been addressed later, but…while I appreciate the commenter who mentioned the edited out profanity allows them to listen with kids around…for those of us who are kidless, don’t mind the profanity and do mind being taken out of the flow of listening by the edit points, is it possible to have an unedited episode available? Since someone had to go in and edit from the original, that would mean an original exists. I wouldn’t even mind if the edited went out over the feed to keep the feed family friendly but I had to come here (or elsewhere) to manually download the unedited one. Thanks, chief.

    1. Hey Widgett,

      Not to worry. I decided that editing out profanity is for the birds, so the eps will be au natural (sp?) going forward.

      More from me soon 🙂

      Kia kaha,


      1. Fantastic news. I too decided that editing profanity from podcasts was for the birds…and few birds listened to my podcasts. Except for some reason we’re really big with egrets. But fact: egrets swear like sailors. So it’s all good.

  38. I really liked this podcast. It was fun to hear a seriously techno one. And you warned everyone in advance. It’s like the detail boxes in 4HB.

    Question. How can artificial sweeteners be quantified for insulin response? Which is the healthier choice. A 20 oz Diet Coke. Or a comparably sized hot coffee with heavy cream and say 4 tsp of sugar? I’ve been telling myself that the coffee is the better choice — more natural. ??

  39. Tim, I loved listening to this podcast. Right up my alley.

    You mentioned gut health as a future topic. I strongly vote yes to that idea. As a person who has had their appendix taken out, I am very interested in the subject.

    Keep the great pod casts coming.

  40. great episode, although you totally botched the George Carlin quote (It’s “Don’t sweat the petty stuff” not “petty things”) maybe it’s petty of me…but George was such a wordsmith, and carefully chose every word for a reason I think.

    1. The man chose every word with tactical precision. The correct quote is “Don’t sweat the petty stuff and don’t pet the sweaty stuff” Tim, shame on you for misquoting the master wordsmith! Tsk Tsk

  41. Hey Tim,

    Loved the episode! As I am a PhD in Biotech myself, it was a bit easier for me to follow. Keep up the good work! I know I’m a bit lagging, but I only listen to the shows when I go running..

    Btw, cool fact to know about epigenetics is that when a woman is pregnant of a baby girl she already has epigenetic effects on her grand children, as the unborn daughter’s primary oocytes already develop before birth.



  42. Hi Tim – Thank you for having such quality guests on the topic of life-extension. I particularly enjoyed the bit about stem cell banking. It would be great if you could expand on that for future podcasts. I am considering a peripheral blood collection method which was not covered here. It is hard to find find a lot of information on that topic.

  43. Great episode! You might read “Enzyme Nutrition” to compliment the information provided by Dr. Patrick. Thanks for the great material Tim.

  44. This is still one of my favorite episodes Tim. I’ve listened to it several times now. The most fascinating idea to me is the hyperthermic conditioning part. More research should definitely be done – it seems like such a promising health benefit. Great show though man, there’s a ton of great info here!

  45. Great show!

    Tim: The explanation you received for “mesenchyme” left much to be desired (no offense to Rhonda of course!). Mesenchyme just means derived from muscle or bone. Mesenchyme is a classification of tissue type, a term we use across all medical specialties. Pleuri/toti/multipotent are specific cell types in embryology.

    -Andrey Y., M.D.


  46. This was a frustrating podcast since I think Rhonda is knowledgeable in many topics of interest to me however I found nothing actionable and the promised nuggets never materialized through the geek speak. I did sign up for her blog though in will dig a little deeper. I listened while running as I am catching up on Tim’s enjoyable podcasts but this one left me with the feeling that without the right form and dosage of magnesium I will get cancer next week.

  47. Tim, did you ever get your wisdom teeth taken out and store the dental stem cells? I just happened on this episode and just happen to be getting two of mine out next month at age 31 and seriously considering it.

  48. I agree, we absolutely need supplementation no matter how well we eat. Thank you for this fascinating insight into the detail on how the human body works and needs these essential micro-nutrients to maintain basic functions not only to have vitality, mental alertness, and to look healthy but also to avoid disease establishing itself.

    I would add, that rather than having to lose oneself in what exactly each of us is missing in terms of individual minerals or vitamins, I do prefer a wholistic medical nutrition model that covers all the bases in one hit! I have seen countless success stories, including my own resolution of liver disfunction and restoration of bone and joint issues ; without complicated lab testing and impossible diet regimens.

    Its important to note that we need all 60 minerals (apart from the 16 vitamins) as minerals need each other to be utilised by the body or they depend on other biochemical actions that need other minerals. Minerals are also needed to render vitamins useful to us (hence a wholistic biological nutritional approach rather than a reductionist or fractionated attempt to fix specific issues). Very important also are the FORM of the mineral ; Metallic minerals (most common supplements) are only 8% bio-available to the body, Chelated minerals (often perceived as the best) are only 40-50% bio-available whereas plant derived colloidal minerals are nearly 100% absorbable… Negative electric charge, Hydrophilic – easy to dissolve without digestion. 200 – 2,000 times smaller than metallic minerals so able to be absorbed readily into the bloodstream. I have very interesting information regarding this if you’ want to know more. Suzanne Young (Mauritius)

  49. Excellent interview. Tim, I do think that you interrupted Rhonda a couple of times that were highly inopportune. When your fascinating expert guest begins a sentence with, “In the next ten years—” and you cut her off? That’s an unforced error 🙂

    Please have her back for another hour. And encourage her to write a book at this level of technical detail.

  50. Awesome as usual. Tim, have you considered colloidal silver for your lyme disease? There’s a lot of historical and empirical background behind it.

    The Nasa and even american hospitals use it to clean their water.

    Should be taken with good care but still, when any drug works, it might be worth a try.

  51. I’m obsessed with your Podcast Tim, thank you so much for bringing all this amazing knowledge to us and keeping me sane in traffic.

    I’m wondering if you’ve come across Mantak Chia. His book, The Multi-Orgasmic Man, might have the answers to your posed challenge of balancing quantity vs quality when it comes to life extension, and specifically with regards to ejaculation 😉

    He’s got fascinating knowledge that I would love for the bigger world to know about, and he’s also funny. I highly recommend that you look into interviewing him – he visits the US a few times a year to teach.


  52. Hi Tim,

    This relates to Rhonda’s podcast interviewing you, but seems this might be the best way to pass on some thoughts to you.

    You guys were talking about your experience with Lyme disease antibiotics inflammation etc.

    I have been managing autoimmune disease for ~7 years with Autoimmune paleo protocol which has been more ketogenic over the last couple of years. I had an abcessed tooth last year and I got crazy carb cravings while I was making my decision about what to do. I decided to have the tooth removed and the abscess came with it, they scraped the socket etc. and the cravings completely disappeared. It makes sense to me that the inflammation associated with the infection shifts our metabolism towards carbohydrate reliance.

    Also you were talking about people thinking the ongoing impacts of heavy duty antibiotic use were actually due to the Lyme disease persisting. My thoughts are about impact of the antibiotics on Mitochondria since they were originally free living bacteria that got incorporated into eukaryotic cells. Impacts on both their function and numbers with antibiotic use. So things that help reduce inflammation and help mitochondrial recovery are super helpful for personal recovery.


    Frankie – Sydney Australia

    1. P.S. Just rereading my comment above, what I was trying to get to is the relationship between insulin resistance and infection which I think is especially strong with bacterial infection e.g. sepsis and endotoxin.

  53. The last thing I would describe myself as being is a person of virtue. I would though describe myself as one who strives to be so. I believe that such virtues as patience, tolerance, temperance, kindness, purity, humility, fear of the Lord, etc. have a huge impact on longevity and health. I believe the opposite vices have the reverse. Of course, not in all cases. At age 79 I have never been a patient in the hospital, do not and have never taken medication other than a rare antibiotic. My most serious illness has been the flu, My eyesight is 2-25 without glasses.I can walk three miles in fifty minutes without becoming fatigued and often do so. Also I cut an acre of grass weekly with a push lawnmower and always feel energized afterwards. I never took nutrients until I was in my mid-50s. I have, however, taken mega doses of vitamin C since my mid 20s. At age 79 I am not too old to appreciate a beautiful woman, and I find Dr. Patrick beautiful.

  54. Hi Tim – I know that you often talk about the MTHFR gene. I am a genetic counselor, and as I listen to you, I become concerned that you’re making people interested in getting “tested for MTHFR” …as if we have this gene all figured out. As you know, the evidence is all over the place, but the bottom line is that this variant has the capacity to really introduce a lot of unnecessary anxiety. It’s a genuine thorn in our side within the genetics community. I wanted to pass along two resources that can help people get a better understanding of this gene and hopefully manage unnecessary anxiety. (1) (2)

  55. Tim, this was information dense and great! Is it possible to have a written transcript of this episode please?

    Thank you,


  56. There is so much great information here. Is there by chance a transcript available anywhere?

  57. The stem cells generally collected from wisdom teeth are of poor quality. Early prophylactic removal of the developing tooth bud yields far higher quality of stem cells which are more multipotent (pluripotent). These tooth buds are not yet calcified and are easy to remove and do not have 6% parasthesia and other morbidities associated with extraction of developed third molars.