How Animals Discover and Use Medicines

This guest post from Dr. Mark Plotkin (@DocMarkPlotkin) features an excerpt from his book Medicine Quest: In Search of Nature’s Healing Secrets. I loved the chapter on how animals use medicinal plants so much that I published the audio version on the podcast. If you prefer the audio version, narrated by Mark, click here.

Mark is an ethnobotanist who serves as president of the Amazon Conservation Team, which has partnered with ~80 tribes to map and improve management and protection of ~100 million acres of ancestral rainforests. He is best known to the general public as the author of the book Tales of a Shaman’s Apprentice, one of the most popular books ever written about the rainforest. His most recent book is The Amazon: What Everyone Needs to Know. You can find my first interview with Mark at

Mark is also the host of the Plants of the Gods podcast, through which you can learn about everything from hallucinogenic snuffs to the diverse formulations of curare (a plant mixture which relaxes the muscles of the body and leads to asphyxiation), and much, much more.


Enter Mark…

Biologists studying animals in the wild are typically discouraged from giving their study animal names so as not to anthropomorphize them; in other words, not to think of them as friends or pets. Jane Goodall — one of the greatest field biologists of all time — has always disagreed. I overheard a discussion between her and another biologist in the early 1980s. The zoologist asked her, “Why do you give your chimps names? Is that really scientific?”

Without missing a beat, Jane asked him, “Do you have a dog?”

“Yes,” he replied.

“Does your dog have a personality,” she asked.

“Of course,” he replied.

“Well,” said Jane, “I bet my chimps have at least as much personality as your dog!”

Many years later — when I was studying the history of wine as medicine in the ancient world — I mentioned the project to Jane. “You know that drinking alcohol wasn’t invented by humans, don’t you? Chimps periodically get drunk on fermented marula fruit, as do elephants and baboons and other species as well!”

As an ethnobotanist who studies how indigenous peoples find and use medicinal plants of the rainforest, this was a revelation. Could some of this medicinal plant wisdom been first learned of from the Animal Kingdom?

In the summer of 1980, I had the opportunity to wander in the once great rainforests of eastern Brazil. The early European explorers were awestruck by the beauty and diversity of these tropical forests, which stretched in an enormous unbroken arc from the easternmost tip of Brazil hundreds of miles south into what is now Paraguay and northern Argentina. However, what remains is a fragment of what once was: small, isolated pockets of forest, home to a handful of species: more than 96 percent of the original forest cover has been destroyed. And as I wandered through those distant patches of jungle, the sounds of trucks, bulldozers, radios, and human voices surrounded me on all sides, a constant reminder that our civilization was in the final throes of obliterating the little that was left.

The forest itself seemed almost empty; the large terrestrial mammals like the jaguar and the peccary that characterize the South American rainforest had been hunted out so thoroughly that I saw not even a pair of footprints. The haunting calls of the toucans and the piercing screeches of the macaws had long been stilled. Of course, these spectacular animals were not the only components that had been eliminated from these forests. In the course of preparing for my trip, I had combed through the early accounts of the first European explorers who had ventured into these jungles almost 500 years earlier; their reports were filled with tales of the tribal warriors who once dominated this complex landscape. Though the jungle had been reduced by over 90 percent of its original range, tribes like the Botocudos and the Tupinikin had been completely exterminated long before my arrival.

What is the medical legacy of these indigenous peoples, and the once great forests in which they thrived? All the commercial medicines derived from the rainforests of Africa, Asia, and the Americas were initially extracted from plants observed in use by local tribespeople. No major medical compound has ever been developed from an eastern Brazilian rainforest plant, and that is undoubtedly because the Botocudos and other tribes were obliterated before any ethnobotanical studies were ever carried out.

Without indigenous people to guide us, how best to determine which plants merit laboratory investigation? Of the 16 parks and protected areas in the country of Suriname in the northeast Amazon, for example, 12 have no indigenous peoples living within the boundaries or nearby, a situation increasingly common in the tropics. If we are to find the new and useful compounds that do occur in the plants, how best to proceed?

American aviators preparing to fly over the jungles of Indochina during the Second World War were taught that the best way to survive if shot down was to “eat what the monkeys eat.” While the overarching value of this advice was probably psychological (some monkeys have chambered stomachs capable of digesting leaves that would poison and possibly kill a human), this recommendation may ironically prove more beneficial for medicinal purposes. For we are learning that rainforest animals also know and use plants for therapeutic purposes. A most extraordinary example comes from research on an endangered species of primate in these same rainforests of eastern Brazil.

In the early 1980s, Karen Strier, then a Harvard graduate student in biological anthropology, traveled to the eastern Brazilian state of Minas Gerais to conduct research on muriquis (also known as woolly spider monkeys), the largest and most apelike of the New World monkeys. Strier’s studies soon led her to some surprising conclusions. The diet of muriquis proved much higher in tannins than those of other monkeys. Because tannins comprise about 50 percent of the anti-dysentery drug Entero‐Vioform, the Harvard scientist wondered if the primates were modifying their diets to kill parasites or control the diarrhea that often accompanies parasite infestation. Subsequent investigation revealed that the muriquis in this forest were completely free of parasites — highly unusual for a rainforest primate. And several of these plants are identical to (or closely related to) species taken by Amazonian Indians to control parasites.

Prior to the onset of the breeding season, Strier noted that the muriqui’s diet consisted primarily of the leaves of two tree species rich in antimicrobial compounds. During that same time of year, the muriquis visit the “monkey’s ear” tree (so named because of the shape of the fruits) to feed. As a general rule, when monkeys find trees laden with edible fruit, they gorge themselves until little remains. Yet Strier wrote that the muriquis consumed a small portion of the fruits before departing, “as if they only need a taste to be satisfied.” Once back at Harvard, she learned that these fruits are rich in stimasterol, a chemical employed in the manufacture of progesterone, which is itself used in birth control pills. Plant hormones can affect animal fertility. Did the monkeys of this forest discover the birth control pills tens of thousands of years before their human cousins did?

Primatologist Dr. Ken Glander of Duke University has spent decades studying the howler monkeys of Central America and reached conclusions that parallel those of Karen Strier. Glander hypothesizes that the howler monkeys eat a selection of plants that allows them to determine the sex of their offspring! He has noted that female howlers consume certain plants before and after copulation that they do not eat at any other time. Over two decades of study, Glander found that some howlers bore only male offspring, while others produced only females, an outcome unlikely due to chance. “Female” sperm (those that carry an X chromosome) do better than “male” sperm (which carry a Y chromosome) in an acidic environment-and vice versa. Could female howlers be controlling the chemistry of their reproductive tract and, if so, why? Glander suggests that plant-derived estrogen-like chemicals may be responsible. He noted that males in a monkey troop often pass more of their genes to the next generation than females are able to do. This would explain why it is often advantageous for a female to produce more males or, if there already exists an overabundance of males, why female offspring are preferable.

The study of how animals use plants for medicinal purposes is termed “zoopharmacognosy” — but our observation of this phenomenon is, without question, an ancient practice. Who has not watched a dog swallow grass to induce vomiting when the animal has eaten something unhealthy it wishes to regurgitate? In a thought-provoking research paper, the brilliant ecologist Dr. Dan Janzen of the University of Pennsylvania wrote, “I would like to ask if plant-eating vertebrates may consume plants on occasion as a way of writing their own prescriptions.” And sometimes animals teach us by their wisdom, other times by their mistakes.

Fatal culinary errors made by North American cows in the early part of the 20th century, for example, led to the development of several blockbuster drugs. One Saturday afternoon in February 1933 in the middle of a howling blizzard, a Wisconsin farmer appeared in the office of chemist Dr. Karl Link carrying a bucket of blood. The man had driven almost two hundred miles from his farm near Deer Park to seek help from the state veterinarian headquartered at the University of Wisconsin in Madison. It was the weekend, however, and the vet’s office was closed, so the desperate farmer wandered into the first building he found where the door was not locked: the biochemistry building. The blood in the bucket he carried would not clot. Several of his cows had recently hemorrhaged to death, and now his bull was oozing blood from his nose. He had been feeding his herd with the only forage he had on hand: spoiled sweet clover. 

This hemorrhagic disease had first been reported in the 1920s from both North Dakota and Alberta, Canada. While specialists determined that feeding the animals spoiled sweet clover was the cause of this malady, they were not able to cure it, nor were they able to isolate the compound in the clover that caused the problem. Their recommendations: destroy the spoiled forage and transfuse healthy blood into the hemorrhagic cattle, the same advice offered by Link. Unfortunately, however, the farmer lacked an alternative fodder to feed his herd, and he was unable to perform blood transfusions in rural Wisconsin during the Depression. 

Troubled by his inability to assist, Link mentioned the problem to German postdoctoral student Eugene Schoeffel. Schoeffel, an educated and idealistic fellow fond of quoting Goethe and Shakespeare, undertook the spoiled clover conundrum as a personal crusade. He and his colleagues analyzed the clover for seven years before identifying and isolating the cause of its lethality: a chemical they named dicumarol. They correctly hypothesized that if too much caused a hemorrhage, a minuscule amount might prove to be a useful anticoagulant. Today, dicumarol (and its synthetic analogues) are commonly employed in humans as anticoagulants, particularly for the prevention and treatment of pulmonary embolism and venous thrombosis. 

The clover analysis serves as an example of a single species yielding a multitude of products. Noticing that one of the synthetic analogues seemed to induce particularly severe bleeding in rodents, Link proposed testing it as a rat poison, thinking it might lack the obvious dangers of more toxic rodenticides like strychnine. Research on this compound was bankrolled by the Wisconsin Alumni Research Foundation — acronym: WARF; when proved effective, it was named warfarin (despite the bellicose connotations, the name came from the acronym of the alumni group!).

In early 1951, an army inductee tried to commit suicide by eating warfarin. He failed to kill himself but did manage to induce a classic case of hemorrhagic sweet clover syndrome. The unhappy soldier was successfully treated with transfusions of normal blood and coagulants. This bizarre incident led to studies and eventual approval of warfarin (renamed Coumadin) as an anticoagulant for human patients. How many cardiac patients realize that their physicians are prescribing rat poison for their ills? 

Yet another aspect of animal behavior has led us to other therapeutic leads. A surprisingly wide variety of creatures ingest and store toxic natural compounds in their own bodies. They do this not for therapeutic reasons, but to employ the poisons for their own purposes, either to equip themselves with the ability to deliver a poisonous bite, or to deter predators from eating them. This is the case with the poisonous pufferfish. 

A deadly nerve poison, tetrodotoxin, occurs in dozens of pufferfish species. These fish concentrate the poison in their internal organs. Though the logical correlation is that humans would go to great lengths to avoid these toxic denizens of the deep, pufferfish are considered a delicacy in Japan. Chefs must undergo special training and then be licensed by the federal government before being permitted to prepare this sought-after delicacy. Despite the rigorous preparation, accidents do happen: every few years, a restaurant customer is poisoned. The result: general numbness, loss of muscle control, and, unless treated, death. Intrigued by the numbness typical of tetrodotoxin envenomation, Japanese physicians have used it as a treatment for pain caused by migraines or menstrual cramps. 

Scientists were surprised to find that the deadly bite of the blue-ringed octopus contained tetrodotoxin. Was it possible that the pufferfish and the octopus were creating the same poison? They found that neither the fish nor the octopus was capable of producing the poison — a bacterium known as Vibrio manufactured it. The fish and the mollusk were ingesting the microbe and then storing the poison in their internal organs to deter predators. In a way, the puffer and the octopus had done our research for us — of the millions of microbes in the sea, they had found one of the deadliest (with potent medical applications) and brought it to our attention, albeit in a most fatal fashion. 

The method of filching a poison from another species and using it for protection has helped us understand how dart poison frogs become toxic. Tropical American dart frogs contain myriad fascinating chemical compounds. Until recently, however, we were unable to determine how the frogs made the poison. When raised in captivity, these amphibians often failed to produce the same toxins. Specimens captured in the wild and placed in captivity may keep their alkaloids. But their progeny possess fewer or none of these alkaloids. 

Hawaii produced an even stranger phenomenon. Poison dart frogs were released in the Manoa Valley on the island of Oahu in 1932. When the descendants of these amphibian immigrants were tested in the lab 50 years after the original introduction, scientists found two of the same types of alkaloids that occur in the original species, which is native to Panama. Another type of alkaloid found in the Panamanian specimens was absent. And scientists found an entirely new alkaloid in the Hawaiian frog that does not occur in the Panamanian version! What is going on here? 

Poison dart frog authority Dr. John Daly hypothesized that: (1) the amphibians make the alkaloids themselves; (2) they made the alkaloids from something that they consumed; or (3) they collected and stored the compounds from a component of their diet, much as the pufferfish does with tetrodotoxin.

The answer to Daly’s hypothesis seems to be a combination of all three. Some of the compounds (or their precursors) are found in poisonous insects eaten by the frog: alkaloids are taken in and stored from beetles, ants, and millipedes. But it was not just a question of ingesting and sequestering any and all alkaloids: when ants containing two different alkaloids were fed to the frogs, the little amphibians stored only one alkaloid in their skin and apparently excreted the other. And, in some instances, the frogs were observed seeking out and consuming particular species of insects that harbored compounds that the frogs typically stored in their own skin. As with the octopus and the pufferfish, these little frogs were finding new and useful chemicals in nature long before we did.

In terms of intentionally using plants for medicinal purposes, the great apes of Africa represent the most sophisticated members of the animal kingdom. Harvard primatologist Dr. Richard Wrangham observed chimpanzees in Uganda’s Kibale Forest consuming a tropical daisy called Aspilia in the early 1980s. While chimps devour many plants in their largely vegetarian diet, Wrangham made note of the unusual behavior surrounding consumption of this species: the leaves of Aspilia were carefully chosen and then swallowed. Furthermore, the primates’ faces appeared to indicate severe distaste, like a child taking castor oil. Because chimps, like people, are prone to parasitic infections, Wrangham hypothesized that the monkeys were consuming these leaves for medicinal (rather than nutritional) purposes. 

Wrangham brought Aspilia specimens to the lab for analysis and received startling results: the plant contained a novel compound (which they named thiarubrine) that proved to have potent antibiotic, fungicidal, and vermicidal properties. Curiously, they also learned that this plant and related species are widely employed by African peoples for a panoply of medicinal uses: from treating cuts to cystitis to gonorrhea. This in turn raised another issue: was it the use of this plant by the chimps that led people to experiment with it in the first place? 

Ethnobotanists — scientists like myself who study people’s use of local plants — have long wondered how a culture learns which species harbor medicinal qualities. While the process of trial and error clearly plays a significant role in this process, might not the plants employed by animals offer a natural starting place for experimentation? 

The thiarubrine story had a bizarre footnote: when scientists retested Aspilia in the lab, they only found thiarubrine in the roots of the plant, which the chimps do not eat. African, European, Japanese, and American research teams have repeatedly confirmed that the primates consume only leaves. Why, then, are parasite-ridden chimps eating the leaves? Primatologist Dr. Michael Huffman, an American scientist who lives in Japan and works in Tanzania, found the answer in an ingenious bit of field research. Huffman and his colleagues found that the chimps’ droppings often contained both Aspilia leaves and intestinal worms that had been impaled on stiff tiny hairs (known as trichomes) on the leaf surface. Though the chimps were taking the leaves as “medicine,” it was not a chemical that killed the parasite, but a physical remedy that simply scraped out and impaled the offending organism. Huffman christened this process the “Velcro effect.” Because of this research, however, scientists had indeed discovered a new antibiotic. 

Huffman, who was inspired to choose a career in primatology by his childhood fascination with H. A. Rey’s Curious George, eventually collected concrete evidence that the chimps were employing other plants as chemical medicines rather than just botanical Velcro. Huffman has focused much of his field research in the Mahale region of Tanzania along the eastern shore of Lake Tanganyika, close to where the explorer Henry Morton Stanley found Dr. David Livingstone more than a century ago (and about 100 miles north of Jane Goodall’s famous site at Gombe Stream). There, Huffman’s guide and mentor is Mohamedi Seifu Kalunde, a soft-spoken elder of the local WaTongwe tribe. Kalunde is both a skilled naturalist and a renowned herbalist. Kalunde and Huffman were tracking a sick female chimp in November 1987 when the chimp stopped in front of a Vernonia bush of the daisy family, tore off a branch, and began peeling the bark. 10 years later, Huffman still vividly recalls the events that transpired: “Mohamedi said, ‘That is very strange. I don’t know why she is eating that because it is very bitter.’ I asked, ‘Do they eat it a lot?’ and he said ‘No.’ Then I asked him if his people made use of it and he said, ‘Yes. We take it for stomach problems.’” Vernonia represents one of the most important and widely used medicinal plants of the African continent. In Ethiopia, it is valued as a treatment for malaria; people in South Africa value it for amoebic dysentery. Tribespeople in the Congo use it for diarrhea, and the Angolans utilize it for upset stomach. In Kitongwe, the language of Huffman’s guide and mentor, Kalunde, the name for Vernonia is “njonso,” which means both “bitter leaf” and “the real medicine.”

As they watched the sick chimp, she finished peeling the bark and began chewing on the stem. She did not swallow it, however, but spit out the chewed remains, only ingesting the bitter sap. Huffman doubts the sap is an “acquired taste” consumed for gustatory purposes — the flavor is exceptionally foul. (Jane Goodall once performed an intriguing experiment, which probably has some bearing on Huffman’s observation: when she gave sick chimps bananas laced with the antibiotic tetracycline, they readily devoured them. However, when she offered the same drug-laden fruits to healthy chimps, they refused them.) Huffman and Kalunde continued to follow the sick chimp, which made a rapid recovery. Prior to consuming the plant sap, the chimp was suffering from constipation, malaise, and lack of appetite. A day later, she had made a spectacular recovery: the researchers had trouble keeping her in sight as she began climbing ridges at a rapid clip.

Of course, a single observation of a single sick chimp cannot be considered convincing proof in and of itself. Yet in December 1991, the research team made similar observations that added credence to their theory. Huffman and Kalunde observed another sick chimp eating Vernonia and managed to test their hypothesis. As they tracked the chimp, they collected samples of her droppings for laboratory analysis. At the time of the first collection, the stools contained 130 nematode eggs per gram. Less than 24 hours later, the egg level was reduced to 15 per gram and the chimp had resumed hunting, an energy-intensive exercise that she appeared unable to perform the day before. When the researchers calculated exactly how much of the plant the animal had ingested, they found that her dosage was almost identical to that taken by ailing tribespeople. The period of recovery — 24 hours — was identical for both people and chimps. And though the plant was common and available year-round, chimps tended to consume it only during the rainy season, when parasite infections are most prevalent.

Working with Japanese colleagues, Huffman had the plant chemically analyzed. Lab works revealed two types of chemical compounds that accounted for the plant’s medicinal use. The plants are rich in sesquiterpene lactones, chemicals found in many botanical species and known to have antihelminthic (anti-worm), anti-amoebic, and antibiotic properties. New sesquiterpene lactones found in these plants demonstrated significant activity against leishmaniasis (a common and disfiguring tropical disease) as well as the deadly drug-resistant falciparum version of malaria.

Appropriately, the first commercial use of these Vernonia extracts may be for animals rather than people. Huffman has been collaborating with colleagues in both Denmark and Tanzania to determine the efficacy of Vernonia extracts in killing a nematode known by the scientific name Osteophagostum stephanostomum (another instance in which the name is longer than the creature itself!). These nematodes (and their close relatives) cause significant loss of livestock, particularly in the tropical world. Current treatments, while effective, are often expensive by Third World standards, and therefore inaccessible. The quality of livestock husbandry in the tropics could be vastly improved by providing farmers with a plant they can grow and use to kill parasites and effectively.

Even if developed successfully, Vernonia would not represent the first example of a useful tropical plant finding its way into the medicine cabinet of the veterinarian rather than the physician. The fruit of the betel palm is the stimulant of choice in many parts of Asia, where local peoples chew it wrapped in a leaf of a local pepper vine. Alkaloids in the fruit provide a chemical stimulus, and some claim that betel is as addictive as tobacco. Several decades ago, chemists isolated an alkaloid from the palm, which they called “arecoline” because the scientific name for the palm genus is Areca. Although initially used by physicians as a human vermifuge (an antiparasitic agent), arecoline was eventually judged too toxic for our own species and it’s currently employed as a treatment for parasites in animals.

Animals often prove “tougher” than humans do; they don’t suffer the side effects some drugs cause in people. Few animals live as long as our species, so they theoretically won’t incur the deleterious effects that may result from taking a drug for many decades.

Hence, many of the drugs (both natural and synthetic) currently in development will be used for animals instead of people (or for both). The magnitude of the veterinary market is enormous, encompassing everything from domestic dogs and cats to zoo animals to cattle, pigs, sheep, and horses that serve as the bases for agricultural operations all over the world. The annual global annual value of veterinary drugs is estimated to be more than 29 billion dollars.

But some plants harbor compounds potentially useful both for human and veterinary medicine. Fig trees dominate some tropical forests, where their fruits serve as major dietary components for both birds and primates. Chimps use the trees for medicinal purposes as well as food. In western Amazon, the sap of one species is so highly valued as a cure for parasitic infections that it is bottled and sold commercially. The leaves of an African species are eaten by chimps in Tanzania probably because they contain proteolytic (protein-destroying) enzymes that kill nematodes, chimpanzees’ most common intestinal parasites. The young leaves — which the chimps eat — contain 600 percent more of the antiparasitic agent than do the older fig leaves, proving in this instance that these primates know their medicinal plants!

Fig sap is also consumed medicinally by another large mammal: the elephant. Presumably these pachyderms value it for its antiparasitic nature, much as local peoples use the plant. But fig trees aren’t the only medicinal plant consumed by the elephants. In the early 1940s, scientists observed Asian elephants devouring the fruits of legume Entada scheffleri before embarking on lengthy treks, leading researchers to hypothesize that the plant may serve as either a stimulant or a painkiller (or could it merely be pachyderm carbo-loading?). For example, a World Wildlife Fund ecologist spent much of 1975 tracking and observing a pregnant elephant in Tsavo Park in southern Kenya. The elephant had a standard routine of covering about three miles a day in search of edible plants. One day, the mother-to-be walked almost 20 miles and devoured an entire tree of the borage (forget-me-not) family. The scientist never observed this creature consume this species before or after this particular incident. Four days later, the elephant gave birth.

While this is not proof of cause and effect, the scientist soon stumbled across a most extraordinary parallel: pregnant women in Kenya prepare and consume a tea of the bark and leaves of this species to induce either labor or abortion! When Michael Huffman related this story to his colleague Kalunde, the Kenyan replied that his grandmother had taught him that WaTongwe women had employed this plant for the same purpose in the past. Huffman noted that the WaTongwe live in southwestern Tanzania, more than one hundred miles south of Tsavo, implying that the custom was probably the case in more than one elephant individual or population.

According to Huffman, Mohamedi learned most of what he knows about medicinal plants from his late grandfather, who gleaned insight into the potential utility of the flora by observing the behavior of the local fauna. Kalunde related the tale of a sick African crested porcupine that dug up and consumed the roots of a local plant known as “mulengelele.” The little creature soon recovered from bouts of diarrhea and lethargy, often the symptoms of a parasite infestation. Kalunde claimed that this led the WaTongwe to begin employing mulengelele to treat parasite infestations among themselves. Huffman cautions that this story may be merely an “interesting teaching device” to pass important information down from one generation to another and adds that medicinal plant use has never before been reported in porcupines. Can we afford to dismiss this as an allegorical tale for transmitting information to children and grandchildren, or should mulengelele be investigated in the lab?

This episode parallels an unforgettable experience I had in the northeast Amazon with a remarkable tribal group known as the Maroons. When slaves were brought to the Amazon in the 17th and 18th centuries, many managed to escape from captivity into the rainforest. There they coalesced into tribal societies very much patterned on the African cultures from which they had been captured and enslaved. They were warriors perhaps by nature but certainly by necessity, as they represented a severe threat to the plantation economy of the local colonies. (As long as there was a “home” in the forest for runaway slaves, servants on the plantation were that much more likely to take up arms and/or escape.) In Brazil, the Maroons managed to organize themselves into the city-state known as Palmares, which was eventually razed to the ground by white plantation owners and their henchmen. In Suriname, however, the Maroons were never conquered, and there these unique African-American cultures continue to thrive.

From an ethnobotanical perspective, the Maroons are endlessly intriguing in that they have an origin in and a relationship with the forest different from that of the local Amerindians. For example, they employ some plants for medicinal purposes that the Amerindians do not use. Because the Native Americans have lived in the forest for thousands of years and the Maroons have only been there several hundred years, it is tempting to assume that the latter know much less about the forest because they are relatively recent arrivals. I came to find out that such is not always the case.

I was visiting the capital of Paramaribo, sitting on the terrace of a bar overlooking the muddy brown Suriname River that flows gently past the city. With me was Chris Healy, an American raised in Suriname, who is an expert on Maroon art and culture. We were speaking about people, plants, and animals of the forest when he told me an exceedingly peculiar tale about the tapir, the largest mammal of the Amazon rainforest. According to Chris, the Maroons claim that tapirs eat the stems of the nekoe plant, defecate into forest streams, and eat the fish that rise to the surface, stunned by compounds in the plants. In fact, nekoe (known elsewhere in Latin America as barbasco or timbo) contains chemicals known as rotenoids that interfere with fishes’ ability to intake oxygen, causing them to float to the surface if nekoe has been added to the water in which they swim. Local peoples (both Amerindians and Maroons) take advantage of this phenomenon by throwing crushed nekoe stems into the river and catching the fish that rise to the surface. This plant serves as the source of rotenone, which is used as a biodegradable pesticide by organic gardeners and was valued by American soldiers during the Second World War to kill mites that had infested their clothing.

Thinking that the Native Americans know more about forest and its creatures than the Maroons do, I queried several Amerindian colleagues about tapirs and nekoe, but they steadfastly denied any connection between the two. However, several Maroons that I interviewed told me that tapirs consume nekoe, defecate the remains in forest streams, and so on. Does this mean that the Maroons learned of the fish-stunning capabilities of nekoe by observing tapirs? Or is this merely something on the order of a fanciful tale concocted to teach youngsters about the value of the vine, much as Huffman suggests may have been the case with the mulengelele and the African crested porcupine?

One of the reasons to suspect that the Maroons may well have learned from the tapirs is that so much more evidence of animal use of medicinal plants has come to light since scientists began searching for it over the course of the past few decades. As mentioned, chimps are the best documented group in terms of plant use for medicinal purposes. (It may be argued that their utilization of healing plants is somehow not particularly representative of the animal kingdom as a whole because these primates are so closely related to us: our DNA is more than 95 percent identical to that of chimps; chimps are more closely related to us than they are to the other great apes, gorillas and orangutans). The great apes are known to employ over 30 species of plants for medicinal purposes. This may well represent what scientists term an “artifact of collection,” meaning that the most attractive and conspicuous animals receive the most attention, hence we conclude that these species use more medicinal plants than other creatures.

In fact, the more we look, the more we find. Even the literature contains a long and extensive list of animals (mostly mammals, probably for reasons noted above) consuming botanicals for purposes that are presumably therapeutic. A recent paper in Science magazine by Jacobus de Roode noted that fruit flies lay their eggs in high ethanol foods (like the fermented marula fruits so beloved by Jane Goodall’s chimps) to deter predation by wasps. Wood ants add antimicrobial resins from pine trees to deter microbial growth much as the ancient Greeks added terebinth resin to wine to prevent spoilage. And sparrows and finches have been found to add cigarette butts to their nests to deter mite infestations, because nicotine is an effective insect repellant.

Yet another example is pigs, who are notoriously prone to parasite worm infestations. Wild boars in both India and Mexico often consume plants with known antihelminthic properties: pigweed in India and pomegranate roots in Mexico.

Yet, there is an unusual twist to this pig story. In India, local people extract and utilize a worm-killing medicine from the pigweed roots. But though pomegranate root bark is known to contain an alkaloid that kills tapeworms, neither the pig nor the pomegranate is native to Mexico: the Spanish conquistadors brought both to the New World. The pigs nonetheless selectively seek out and consume the roots of this tree as their ancestors once did in the Old World.

In the course of his decades of research on tropical plants and animals, the aforementioned ecologist Dan Janzen unearthed a paper published in 1939 that noted that the Asian two-horned rhino was observed eating so much of the tannin-rich bark of the red mangrove that its urine was stained bright orange. Tannins are a major component of some over-the-counter antidiarrheal preparations such as Entero‐Vioform. Janzen has noted that the concentration of tannins in the bladder of the rhino necessary to change the color of its urine was undoubtedly sufficient to have an impact on parasites in the creature’s bladder or urinary tract.

These animal-plant interactions have also been observed outside the tropics. Dr. Shawn Sigstedt, a laconic, Harvard-trained ethnobotanist, has focused his studies on the plants, animals, and peoples of American West. Sigstedt’s favorite plants are a small genus of herbs known as Ligusticum, but he is not the only one captivated by this somewhat nondescript little plant. When bears encounter the plant, they exhibit peculiar behavior: Ligusticum functions as an ursine catnip. Sigstedt once observed Ligusticum roots thrown into a brown-bear zoo enclosure, and a brawl ensued. The victor carried the roots to a corner of the cage, chewed them up, spit them out, and rubbed them all over his face and body. Both grizzlies and polar bears have proven similarly enamored of this little plant.

The Navajos of northern Arizona taught Sigstedt that the name for Ligusticum in their language translated into English means “bear medicine.” These tribal peoples value this plant as a treatment for many different ailments, treatments whose effectiveness is borne out by chemical analysis that documented the presence of compounds that are anticoagulant and antibacterial, as well as other chemicals that may combat both fungi and insect vermin. To the Navajos, the bear is a sacred creature; in their creation tales, these animals are considered experts in the use of medicines.

Sigstedt was a bit surprised that his findings were considered so astonishing when he began reporting them in the late 1980s. “After all,” he said, “deer and elk have long been known to chew aspen bark that contains compounds similar to aspirin. Why should bears be any less adept at using plants than these creatures?” He also feels that people’s amazement upon discovering that bears were using these plants may have more to do with our perception and categorization. “We tend to place a somewhat artificial barrier between food and medicine where an accurate description is probably better described as a complex mosaic.”

This epicurean animal behavior noted by Sigstedt has also been observed in tropical America. Coatimundis, long-nosed relatives of the raccoon, have been observed rubbing the resin of a tropical relative of myrrh into their fur, presumably to kill or repel lice, mosquitoes, ticks, or other noxious vermin. The capuchin monkeys of tropical America have similar practices but are known to utilize a wider variety of plant species. Capuchins have been observed rubbing eight different plants into their fur. Of these, four (Hymenaea, Piper, Protium, and Virola) rank among the most common medicinal plants used by tribal peoples of the Amazon, and at least two of these are used by the Native Americans to treat skin problems.

Capuchin monkeys in Costa Rica massage a mixture of Hymenaea resin and rainwater into their fur. The Suriname Maroons collect this same dried resin and make it into a tea to treat diarrhea or burn it to keep away flying insects. Laboratory analysis has revealed that this resin harbors compounds that repel insects, and anthropologists have observed these monkeys rubbing four other plant species into their fur as well. Peasants in the region use three related species to repel insects or treat skin problems. And the Trio peoples who live just south of the Maroons in the northeast Amazon have repeatedly told me they watch and learn medicinal species by observing the primates in their rainforest home.

As I said, birds appear to be making use of plants as both medicines and pesticides. Investigators were puzzled as to why penguins had almost no parasites or other harmful microorganisms in their digestive tract. Further field study revealed that the penguins were consuming blue-green algae on a regular basis, and these marine organisms are often loaded with potent chemical compounds.

Birds most definitely use plants for non-food purposes, which could conceivably lead us to new and useful compounds. Hawks have long been known to place sprigs of green leaves in their nests. Birders now note that hawks select only the live branches of certain tree species and replace the dead or dying leaves in their nests with fresh material every few days. The red-tailed hawk uses the leaves of the cottonwood and quaking aspen, while the bald eagle chooses sedge and the needles of the white pine. In a classic study of this phenomenon, Dr. Bradley McDonald and his colleagues found that seven species of raptors (hawks and their relatives) were using over 12 species of plants. Though other scientists have advanced hypotheses to explain this behavior, from camouflaging the nest to advertising nest occupancy, McDonald’s group tested these plants in the lab and found that all effectively repel insects (in this case, houseflies, although they suggest that these leaves are also noxious to other vermin like mites as well as bacteria). Because these birds are carnivores, the adults regularly carry dead or dying creatures to the nest to feed their offspring. The blood and decomposing flesh of these prey items attract a steady stream of insects and bacteria that have the capacity to weaken and kill the young birds. By using the green plants that they do, the adult raptors protect their offspring in what is probably the first-known ornithological case of preventative medicine and maybe even antibiotics.

Compared to the trees of the temperate forest, the chemical composition of rainforest tree leaves is relatively unstudied. In MacDonald’s study, he noted that antibacterial compounds had already been isolated from the leaves of one of these plant species before he began his study. Similar investigations of whether tropical birds employ local leaves for repellent and/or antibacterial purposes are now under way. But Neil Rettig, the foremost authority on the world’s largest eagle, the Amazonian harpy, has already observed these magnificent creatures applying live branches of the giant Mora tree in their nests in a similar fashion. And what might be an insect repellent for the birds might conceivably one day prove to be a safe and effective insect repellent or antibiotic for us. 

If we can find new painkillers from frogs, new stimulants from porcupines, new antiparasitics from penguins, new antibiotics from chimps, and new contraceptives from wooly spider monkeys, what else might be out there, in the forest, on the prairie, or inside the coral reef, being used by local species and awaiting our discovery of its benefit to our own species? What might have already been lost? When the Portuguese first arrived on the eastern shores of Brazil almost 500 years ago, the population of muriqui monkeys probably numbered in the hundreds of thousands. Now their population has been reduced to a few hundred individuals, and more than 90 percent of their once magnificent rainforests has been destroyed.

Who knows what we lost, either in terms of the actual chemicals, the species that produced them, or the primate knowledge of how to use them — not only for their benefit but, potentially, for ours as well? 

Excerpted and adapted from Medicine Quest: In Search of Nature’s Healing Secrets by Mark J. Plotkin. Copyright © 2000 by Mark J. Plotkin. Excerpted by permission of Viking Adult, an imprint of Penguin Books. All rights reserved. No part of this excerpt may be reproduced or reprinted without permission in writing from the publisher.

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3 Replies to “How Animals Discover and Use Medicines”

  1. I’m Juliano Carvalho, Brazilian, married and father of Jose Lucas, Juliana and Letícia, businessman and a big fan of his work and his life story, I’m an entrepreneur by nature, I wish one day to be able to tell my story. But right now I would like to propose a partnership for you. Being very direct and objective and if you are interested I will be willing to answer all your questions and better present a work and development plan. I really want to translate all your material (podcasts) and other articles that you might find interesting for the Brazilian public, I really believe in your work and in what you can do for people as you have been doing for me. I don’t find anyone in Brazil who has a history and work like yours and I believe that firstly we can help thousands of people more, secondly I will feel very fulfilled doing this work, among other numerous benefits and gains that we may have. Every day I reread the chapters of some of your books that I’ve read (3) and in addition to other interviewees that you came to introduce me to and that I’m also a follower today. I could talk and describe my idea for hours but this
    At the moment I would like to have your interest in this possible project, podcast or in any way to translate your material for thousands more people in Portuguese in Brazil and around the world. I’m eternally grateful to you just for being here trying because I feel better every day and more able to go as far as my soul yearns and much of this ability and will came from your teachings (sharing) . Hug

    Sou Juliano Carvalho, brasileiro, casado e pai de Jose Lucas, Juliana e Letícia, empresario e um grande fã de seu trabalho e de sua historia de vida, sou um empreendedor por natureza, desejo um dia poder contar minha historia. Mas nesse momento gostaria de propor uma parceria para você. Sendo bem direto e objetivo e caso tenha interesse estarei disposto a responder todas as suas duvidas e apresentar melhor um plano de trabalho e desenvolvimento. Quero muito traduzir todo seu material (podcasts) e outros artigos que você possa achar interessante para o publico brasileiro, acredito muito no seu trabalho e no que pode fazer pelas pessoas assim como vem fazendo por mim. Não encotro ninguem no Brasil que tenha uma historia e trabalho como o seu e acredito que em primeiro lugar podemos ajudar milhares de pessoas mais, em segundo vou me sentir muito realizado fazendo esse trabalho, dentre outros inumeros beneficios e ganhos que poderemos vir a ter. A cada dia mais releio os capitulos de algum livro seu que ja li (3) e além de outros entrevistados que vcoê veio a me apresentar e que hoje também sou seguidor. Poderia falar e descrever minha ideia por horas mas nesse
    momento gostaria inicialmente de ter seu interesse nesse possivel projeto, podcast ou de qualquer forma que seja traduzir o seu material para milhares mais de pessoas em português no Brasil e no mundo. Já lhe sou eternamente grato só por estar aqui tentando pois me sinto a cada dia melhor e mais capaz de ir tão longe quanto minha alma anseia e muito dessa capacidade e vontade veio de seus ensinamentos (compartilhamentos) . Abraço

  2. Bear is often called the spirit of Healer in Native America. Healers studied bears to see what they ate when not well, and out of this came the official Materia Medica, the American herbal for doctors.

  3. I love the Tim Ferriss podcast and I like working to be a better person. Part of that for me is making the world a better place, not just for people but for eco systems or life, plants and animals, fresh air, clean environment. I notice I can’t find any relevant tags for your blogs on this. And I think that everything we do depends on these things. So I nominate Julie Bargmann who just won the inaugural Cornelia Hahn Oberlander International Landscape Architecture Prize for reclaiming toxic industrial sites and turning them into city parks of beauty and history and calm joy. There’s not much on the interwebs on how she decontaminates sites and that process interests me too. There are many interesting people who might not be writing lots of books but they are winning awards and making the world a better place.

    Another category in the space is town planning for social well being – ie how to have a better life by improving the city you live in. I don’t know the best people in this space but I know of the Garden City Movement from 100 years ago and how it underpins this kind of town planning and why they decided that parks are really important to the health of humans… Has to do with the industrial revolution destroying the health of urban people.

    In the interests of making the world a better place, and me a better person – the more I know about these kinds of things the better. Happy interviewing.