“If medicine wants to focus on prevention, there’s no better tool than nutrition.” – Dominic D’Agostino
Dr. Dominic “Dom” D’Agostino (@DominicDAgosti2) is an assistant professor in the Department of Molecular Pharmacology and Physiology at the University of South Florida Morsani College of Medicine, and a senior research scientist at the Institute for Human and Machine Cognition (IHMC). He has also deadlifted 500 pounds for 10 reps after a seven-day fast.
Many of you sent enthusiastic follow-up questions after the last conversation we had, so Dom took the time to answer your most popular questions. In particular, he focused on ketosis, ketones, and the ketogenic diet — so you can consider this a ketosis master class (especially if you combine both episodes, though this one does stand alone).
It takes a few minutes for Dom to warm up — so be patient! If you have an interest in these types of metabolic therapies, whether for performance enhancement, endurance, weight loss, or fighting cancer, diabetes, or any number of other maladies, you will find a gem within this episode.
If you only have 5 minutes, listen to Dom’s thoughts on how much protein you should eat on a ketogenic diet.
- Listen to it on iTunes.
- Stream by clicking here.
- Download as an MP3 by right-clicking here and choosing “save as.”
Want to hear my first interview with Dom D’Agostino? — Listen to our in-depth conversation here. In this episode, we discuss fasting, heavy deadlifts, and the end of cancer (stream below or right-click here to download):
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QUESTION(S) OF THE DAY: What was your favorite quote or lesson from this episode? Please let me know in the comments.
Scroll below for links and show notes…
Selected Links from the Episode
- Connect with Dom D’Agostino:
- First mega-hit episode with Dom
- Dom’s favorite options for canned sardines: kingoscar.com and wildplanetfoods.com
- Crown Prince Natural Smoked Oysters
- Dom’s most recommended ketogenic diet resource
- The modified Atkins diet at John Hopkins
- The Ketogenic Diet for Type 1 Diabetes by Ellen Davis and Keith Runyan
- Abbott Precision Xtra Glucose Monitor
- Freestyle Precision Neo Glucose Meter
- Ketonix Breath Ketone Test Monitor
- ATP hydrolysis
- How Wasting Is Saving: Weight Loss at Altitude Might Result from an Evolutionary Adaptation by Andrew J. Murray and Hugh E. Montgomery
- Peter Attia’s lecture at IHMC — An Advantaged Metabolic State: Human Performance, Resilience and Health
- Rebecca Rusch and Patrick Sweeney Climb Kilimanjaro for World Bicycle Relief
- Acetazolamide (Diamox)
- Exogenous ketones
- Triiodothyronine (T3)
- Functional hypothalamic amenorrhea
- Quest Nutrition MCT Powder
- The Gut’s Microbiome Changes Rapidly with Diet by Rachel Feltman, Scientific American
- Alessio Fasano’s lecture at IHMC — The Gut Is Not Like Las Vegas: What Happens in the Gut Does Not Stay in the Gut
- Lactobacillus bifidus probiotics
- The Charlie Foundation for Ketogenic Therapies
- Keto Motive
- KetoDiet app
- MRM Veggie Elite
- LDL cholesterol
- HDL cholesterol
- The Ketogenic Diet: A Treatment for Children and Others with Epilepsy by John Freeman MD, Eric Kossoff, and Millicent Kelly
- 3 Keys To Dialing In Your Macronutrient Ratios, Bodybuilding.com
- Interview with Ketone Expert Dr. Richard Veech on Bulletproof Radio
- My Experience with Exogenous Ketones by Peter Attia
- What Are Ketone Salts?, Ben Greenfield Fitness
- Metabolism of (R,S)-1,3-butanediol acetoacetate esters, potential parenteral and enteral nutrients in conscious pigs by Henri Brunengraber, et al.
- beta-Hydroxybutyric acid
- Fatty acid oxidation disorders
- PubMed search for “MADD ketones”
- Kegenix Exogenous Ketones
- Keto // OS by Pruvit
- Keto // KREME by Pruvit
- Kettle & Fire bone broth
- Scivation Xtend Perform
- Vitamin D3 — 5000iu if you’re inside all day; 1000iu if you spend time in the sun.
- Magnesium Citrate
- Magnesium Chloride
- Magnesium Glycinate
- Hepatic Glycogenolysis
- Why is there so much resistance among dieticians and researchers toward ketosis despite evidence in its favor? [07:12]
- Can you gain muscle size and strength on a ketogenic diet? [15:20]
- How much protein should you take in with a ketogenic diet? [16:21]
- What is the impact of the ketogenic diet on Type 1 diabetes? [19:16]
- Is it better to analyze ketone production by breath or blood? [27:42]
- How does ketosis affect performance at altitude? [30:53]
- Are there any differences females need to be aware of when considering a ketogenic diet? [35:53]
- Can a female obtain a sub-10 percent body fat with a ketogenic diet? [40:43]
- How does ketosis affect the microbiota? [44:53]
- Is counting calories just as important as tracking fat intake and carb restriction if you want to avoid weight gain? [52:00]
- What are Dom’s nutritional tricks to surviving scientific conferences where the food is often less than healthy? [55:36]
- What stimulants aid in ketosis? [58:53]
- Can a vegetarian or vegan follow a ketogenic diet? [1:05:01]
- Should you be concerned if a ketogenic diet increases your LDL or LDL-P (bad cholesterol)? [1:08:55]
- Elevated triglycerides? A ketogenic diet isn’t for everyone. [1:14:17]
- Is it dangerous to use ketone salts? [1:15:29]
- What’s Dom’s advice for people suffering from fatty acid oxidation disorders? [1:24:39]
- Does Dom really support Kegenix? [1:29:40]
- What are Dom’s go-to products? [1:37:21]
- Are exogenous ketones only useful in a state of ketosis, or would they benefit someone who is not keto-adapted? [1:45:28]
- Can exogenous ketones combined with a low-carb diet (but not a ketogenic diet) still give some or all of the benefits of a strict ketogenic diet? [1:48:38]
- Laird Hamilton
- Patrick Arnold
- Erik Kosoff
- Andrew Koutnik
- George F. Cahill, Jr.
- Dr. Richard Veech
- Peter Attia
- Patrick Sweeney
- Rebecca Rusch
- Shannan Yorton Penna
- Alessio Fasano
- Dr. Rhonda Patrick
- Beth Zupec-Kania
- Henri Brunengraber
- Dave Asprey
- Ben Greenfield